Ceroxime
Generic Name
Cefuroxime Axetil
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ceroxime 125 mg suspension | ৳ 198.00 | N/A |
Description
Overview of the medicine
Ceroxime 125 mg Suspension is an antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, ear, throat, urinary tract, and skin. It belongs to the cephalosporin class of antibiotics.
Uses & Indications
Dosage
Adults
Not typically used in adults at 125 mg strength. Standard adult doses are 250-500 mg twice daily depending on infection severity.
Children
Most infections: 125 mg twice daily. Otitis media/more severe infections: 250 mg twice daily. Infants aged 3 months to 2 years: 10 mg/kg twice daily (max 125 mg twice daily). Children 2-12 years: 15 mg/kg twice daily (max 250 mg twice daily for otitis media).
Renal_impairment
Dosage adjustment is necessary in patients with significantly impaired renal function (creatinine clearance < 30 ml/min).
How to Take
Take orally. For optimal absorption, Ceroxime suspension should be taken with food. Shake the bottle well before each use. Use the provided measuring device for accurate dosing.
Mechanism of Action
Cefuroxime axetil is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the disruption of peptidoglycan synthesis, causing bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved approximately 2-3 hours after oral administration with food.
Excretion
Cefuroxime is excreted unchanged by glomerular filtration and tubular secretion in the urine. Approximately 50% of an administered dose is excreted within 12 hours.
Half life
The plasma elimination half-life is approximately 1 to 1.5 hours.
Absorption
Cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases in the intestinal mucosa and blood to cefuroxime. Absorption is enhanced when taken with food.
Metabolism
Cefuroxime is not metabolized in the liver.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the AUC of cefuroxime and reduces its renal clearance.
Oral Anticoagulants
Concomitant use with oral anticoagulants may increase INR values.
Oral Contraceptives
Cefuroxime may decrease the efficacy of oral contraceptives (use alternative birth control).
Antacids/H2 blockers
May decrease the bioavailability of cefuroxime axetil, especially when taken shortly before or after meals.
Storage
Store the unconstituted powder at room temperature (below 30°C) in a dry place, away from direct sunlight. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose of cefuroxime can lead to neurological sequelae including encephalopathy, convulsions, and coma, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Limited data in pregnant women suggest no increased risk of malformations. Use during pregnancy should be considered only if the benefits outweigh the risks. Cefuroxime is excreted in small amounts in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, any other cephalosporin, or to any of the excipients.
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Probenecid
Concomitant administration of probenecid increases the AUC of cefuroxime and reduces its renal clearance.
Oral Anticoagulants
Concomitant use with oral anticoagulants may increase INR values.
Oral Contraceptives
Cefuroxime may decrease the efficacy of oral contraceptives (use alternative birth control).
Antacids/H2 blockers
May decrease the bioavailability of cefuroxime axetil, especially when taken shortly before or after meals.
Storage
Store the unconstituted powder at room temperature (below 30°C) in a dry place, away from direct sunlight. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose of cefuroxime can lead to neurological sequelae including encephalopathy, convulsions, and coma, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. Limited data in pregnant women suggest no increased risk of malformations. Use during pregnancy should be considered only if the benefits outweigh the risks. Cefuroxime is excreted in small amounts in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unconstituted powder: typically 24-36 months. Reconstituted suspension: stable for 7-10 days when stored in a refrigerator.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefuroxime axetil has undergone extensive clinical trials demonstrating its efficacy and safety for various bacterial infections in both adult and pediatric populations. Ongoing post-marketing surveillance and studies continue to monitor its profile.
Lab Monitoring
- Monitor renal function (creatinine, BUN) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Periodically monitor complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course of antibiotics, even if symptoms improve.
- Advise parents on proper measurement and administration of the suspension for pediatric patients.
- Counsel on potential GI side effects and strategies to manage them (e.g., taking with food).
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Take the suspension with food to improve absorption and reduce stomach upset.
- Shake the bottle well before each use and measure the dose accurately using the provided device.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ceroxime 125 mg Suspension may cause dizziness. Patients should be advised to be cautious when driving or operating machinery until they are sure the medicine does not adversely affect them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure adequate rest to support recovery.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Ceroxime Brand
Other medicines available under the same brand name
