Cipcin
Generic Name
Ciprofloxacin 250 mg Suspension
Manufacturer
Leading Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cipcin 250 mg suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Cipcin 250 mg Suspension is an antibiotic used to treat a wide range of bacterial infections, including those affecting the respiratory tract, urinary tract, skin, and bones. It belongs to the fluoroquinolone class of antibiotics.
Uses & Indications
Dosage
Adults
Typically 250-750 mg orally twice daily, depending on the infection.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Dosage reduction is required for patients with severe renal impairment.
How to Take
Take orally, with or without food. Do not take with dairy products or calcium-fortified juices alone. Shake suspension well before use. Use the measuring device provided.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
1-2 hours (peak plasma concentration)
Excretion
Primarily excreted renally (50-70% as unchanged drug) and to a lesser extent via bile/feces.
Half life
Approximately 3-5 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.
Metabolism
Partially metabolized in the liver (10-20%) to less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with tizanidine
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and somnolence.
Theophylline
May increase serum theophylline levels, potentially leading to toxicity. Monitor levels.
Antacids/Calcium supplements
Reduce absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store dry powder below 30°C. Store reconstituted suspension at room temperature (15-30°C) or refrigerated (2-8°C), protected from light, and do not freeze.
Overdose
Symptoms of overdose include acute renal failure. Treatment is supportive and symptomatic; hemodialysis or peritoneal dialysis may aid in removal.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Ciprofloxacin is excreted in breast milk and may cause adverse effects in the infant; discontinue nursing or the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant administration with tizanidine
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR.
Tizanidine
Concomitant use is contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and somnolence.
Theophylline
May increase serum theophylline levels, potentially leading to toxicity. Monitor levels.
Antacids/Calcium supplements
Reduce absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
Storage
Store dry powder below 30°C. Store reconstituted suspension at room temperature (15-30°C) or refrigerated (2-8°C), protected from light, and do not freeze.
Overdose
Symptoms of overdose include acute renal failure. Treatment is supportive and symptomatic; hemodialysis or peritoneal dialysis may aid in removal.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Ciprofloxacin is excreted in breast milk and may cause adverse effects in the infant; discontinue nursing or the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder); 14 days (reconstituted suspension) when stored as directed.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of ciprofloxacin across various bacterial infections. Ongoing research continues to explore its use in new indications and resistance patterns.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance)
- Liver function tests (ALT, AST)
- Blood counts (CBC) during prolonged therapy
- INR for patients on warfarin
Doctor Notes
- Emphasize the importance of completing the full course to prevent resistance.
- Advise patients on potential tendon-related adverse effects and to seek immediate medical attention if they occur.
- Counsel on drug interactions, especially with dairy products and polyvalent cations.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Stay well-hydrated.
- Avoid excessive sunlight exposure.
- Report any tendon pain, swelling, or inflammation immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness; caution should be exercised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Balanced diet.
- Avoid alcohol as it may exacerbate some side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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