Cipcin
Generic Name
Ciprofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cipcin 500 mg tablet | ৳ 15.06 | ৳ 150.60 |
Description
Overview of the medicine
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections, including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
Typical dose for most infections is 500 mg orally twice daily. Duration varies from 7 to 14 days depending on the infection.
Elderly
No specific dose adjustment is required based solely on age, but renal function should be assessed, and dosage adjusted if renal impairment is present.
Renal_impairment
Dosage must be adjusted based on creatinine clearance (CrCl). For CrCl 30-60 mL/min, 250-500 mg every 12 hours. For CrCl <30 mL/min, 250-500 mg every 18-24 hours.
How to Take
Administer orally, with or without food. Do not take with dairy products (milk, yogurt) or calcium-fortified juices as these can significantly reduce absorption. Take with a glass of water. Should be taken at least 2 hours before or 6 hours after antacids containing magnesium or aluminum, sucralfate, didanosine (chewable/buffered tablets or pediatric powder), or iron/zinc supplements.
Mechanism of Action
Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid, clinical improvement can be observed within hours to days depending on the infection type and severity.
Excretion
Primarily via urine (renal) as unchanged drug and metabolites; some excretion occurs via feces.
Half life
Approximately 3-5 hours in adults with normal renal function.
Absorption
Rapid and well-absorbed after oral administration. Bioavailability is approximately 70-80%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Partially metabolized in the liver to four active metabolites, but the parent drug remains the predominant form in systemic circulation.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolones
- Concurrent use with tizanidine
- Patients with a history of myasthenia gravis
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
Enhanced anticoagulant effect, increased risk of bleeding. Monitor INR/PT.
Tizanidine
Concurrent use contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and sedation.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity. Monitor theophylline levels.
Corticosteroids
Increased risk of tendinitis and tendon rupture.
Antacids (Mg/Al), Sucralfate, Didanosine, Iron/Zinc Supplements
Reduced absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
QT-prolonging drugs (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants)
Increased risk of QT prolongation and arrhythmia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of acute overdose, gastric emptying by induced emesis or gastric lavage should be considered. Observe the patient carefully and give supportive treatment. Maintain adequate hydration. Hemodialysis or peritoneal dialysis remove only a small percentage of ciprofloxacin from the body.
Pregnancy & Lactation
Pregnancy: Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Ciprofloxacin is excreted into breast milk and may cause adverse effects in a breastfed infant (e.g., arthropathy). A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to ciprofloxacin or other quinolones
- Concurrent use with tizanidine
- Patients with a history of myasthenia gravis
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
Enhanced anticoagulant effect, increased risk of bleeding. Monitor INR/PT.
Tizanidine
Concurrent use contraindicated due to increased tizanidine plasma concentrations, leading to hypotension and sedation.
Theophylline
Increased plasma levels of theophylline, potentially leading to toxicity. Monitor theophylline levels.
Corticosteroids
Increased risk of tendinitis and tendon rupture.
Antacids (Mg/Al), Sucralfate, Didanosine, Iron/Zinc Supplements
Reduced absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.
QT-prolonging drugs (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants)
Increased risk of QT prolongation and arrhythmia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of acute overdose, gastric emptying by induced emesis or gastric lavage should be considered. Observe the patient carefully and give supportive treatment. Maintain adequate hydration. Hemodialysis or peritoneal dialysis remove only a small percentage of ciprofloxacin from the body.
Pregnancy & Lactation
Pregnancy: Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Ciprofloxacin is excreted into breast milk and may cause adverse effects in a breastfed infant (e.g., arthropathy). A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in pharmacies, hospitals, and medical supply stores
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety for a broad range of bacterial infections. Ongoing post-marketing surveillance and studies continue to refine its use and understand long-term effects, including risks associated with fluoroquinolones.
Lab Monitoring
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete Blood Count (CBC)
- INR/PT (for patients on warfarin)
- Electrolytes if prolonged diarrhea
Doctor Notes
- Ensure proper bacterial susceptibility testing before initiating therapy, if possible, to guide appropriate antibiotic selection.
- Counsel patients on the importance of completing the full course of treatment to prevent antibiotic resistance and recurrence.
- Advise patients about potential serious adverse effects such as tendinitis/tendon rupture, peripheral neuropathy, and CNS effects, and to report these immediately.
- Avoid in patients with a history of myasthenia gravis due to exacerbation risk and severe hypersensitivity reactions.
Patient Guidelines
- Take the full course of medication as prescribed, even if symptoms improve.
- Avoid taking with dairy products or calcium-fortified juices.
- Stay well-hydrated during treatment.
- Avoid excessive exposure to sunlight or artificial UV light; use sunscreen and protective clothing.
- Report any tendon pain, numbness, tingling, or unusual muscle weakness immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Ciprofloxacin may cause dizziness, lightheadedness, or drowsiness, which could impair your ability to drive or operate machinery. Exercise caution until you know how the medication affects you.
Lifestyle Advice
- Maintain good hydration throughout the day.
- Follow a balanced diet.
- Avoid alcohol, as it may exacerbate some side effects (e.g., dizziness).
- Avoid strenuous exercise that may stress tendons during treatment.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Cipcin Brand
Other medicines available under the same brand name
