Cipcin
Generic Name
Ciprofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| cipcin 750 mg tablet | ৳ 18.08 | ৳ 72.30 |
Description
Overview of the medicine
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
The usual adult dosage varies depending on the infection. For severe or complicated infections, 750 mg orally once daily or 500 mg orally twice daily. Duration varies from 7 to 14 days, or longer if necessary.
Elderly
Similar to adults, but dose adjustment may be necessary based on renal function.
Renal_impairment
Dose reduction is required for patients with creatinine clearance ≤ 30 mL/min. Consult prescribing information for specific guidelines.
How to Take
Take orally with or without food. Do not take with dairy products (milk, yogurt) or calcium-fortified juices alone, as these can decrease absorption. Ensure adequate hydration.
Mechanism of Action
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bactericidal action.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved 1-2 hours after oral administration.
Excretion
Primarily excreted renally (approximately 50-70% as unchanged drug in urine); some fecal excretion.
Half life
Approximately 3-5 hours in adults with normal renal function.
Absorption
Rapid and well absorbed from the gastrointestinal tract; bioavailability is approximately 70%.
Metabolism
Undergoes partial hepatic metabolism to less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ciprofloxacin or other fluoroquinolones.
- Concomitant administration with Tizanidine.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
Drug Interactions
Warfarin
Potentiation of anticoagulant effects.
Tizanidine
Significantly increased Tizanidine exposure, contraindicated.
Theophylline
Increased plasma levels of Theophylline, leading to toxicity.
Antacids/Mineral supplements
Reduced Ciprofloxacin absorption.
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
In case of an overdose, symptomatic and supportive care should be instituted. Gastric lavage may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., arthropathy). Use only if the potential benefit justifies the potential risk.
Side Effects
Contraindications
- Hypersensitivity to Ciprofloxacin or other fluoroquinolones.
- Concomitant administration with Tizanidine.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
Drug Interactions
Warfarin
Potentiation of anticoagulant effects.
Tizanidine
Significantly increased Tizanidine exposure, contraindicated.
Theophylline
Increased plasma levels of Theophylline, leading to toxicity.
Antacids/Mineral supplements
Reduced Ciprofloxacin absorption.
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
In case of an overdose, symptomatic and supportive care should be instituted. Gastric lavage may be considered. Maintain adequate hydration.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., arthropathy). Use only if the potential benefit justifies the potential risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ciprofloxacin has been extensively studied in numerous clinical trials establishing its efficacy and safety across various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance)
- Liver function tests (ALT, AST)
- Complete Blood Count (CBC) (for prolonged therapy)
Doctor Notes
- Counsel patients on potential severe adverse effects, especially tendinitis/tendon rupture and neurological effects.
- Monitor renal function, especially in elderly and renally impaired patients, and adjust dose accordingly.
- Avoid co-administration with tizanidine.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Avoid excessive sun exposure and use sunscreen.
- Report any tendon pain, numbness, tingling, or weakness immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, lightheadedness, or visual disturbances. Avoid driving or operating machinery until you know how Ciprofloxacin affects you.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid alcohol as it may worsen dizziness or other CNS effects.
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