Deflazit
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflazit 18 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Deflazit 18 mg Tablet contains Deflazacort, a corticosteroid used to treat various inflammatory and autoimmune conditions, including Duchenne Muscular Dystrophy (DMD). It acts as an anti-inflammatory and immunosuppressant.
Uses & Indications
Dosage
Adults
Varies widely based on condition and severity. For Duchenne Muscular Dystrophy: typically 0.9 mg/kg/day, adjusted based on clinical response and tolerability. For other conditions: initial doses range from 6 mg to 90 mg daily, tapered as per medical advice.
Elderly
Use with caution; lower initial doses may be appropriate. Monitor for adverse effects.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe renal impairment.
How to Take
Take orally, with or without food, usually once daily in the morning. Swallow the tablet whole with water.
Mechanism of Action
Deflazacort binds to glucocorticoid receptors, modulating gene expression, reducing the synthesis and release of inflammatory mediators, and suppressing immune responses.
Pharmacokinetics
Onset
Varies by condition; anti-inflammatory effects generally observed within hours to days.
Excretion
Mainly through urine (approximately 70%) as metabolites, with some excretion in feces.
Half life
Parent drug: approximately 1-2 hours. Active metabolite (21-desacetyl deflazacort): approximately 1.5-3 hours. Biological effects persist longer.
Absorption
Rapidly absorbed from the gastrointestinal tract and immediately converted to its active metabolite, 21-desacetyl deflazacort.
Metabolism
Primarily hepatic, via esterase hydrolysis to its active metabolite, followed by hydroxylation.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during Deflazacort therapy
Drug Interactions
Antidiabetic agents
May reduce the hypoglycemic effect of antidiabetic drugs, requiring dose adjustment.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
CYP3A4 Inducers (e.g., rifampin, phenytoin)
May decrease Deflazacort levels, reducing efficacy.
Diuretics (e.g., thiazides, loop diuretics)
Increased risk of hypokalemia.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Increased risk of gastrointestinal ulcers and bleeding.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May increase Deflazacort levels, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include an exaggeration of known side effects. Management is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Deflazacort is excreted in breast milk; advise caution or consider alternative feeding methods during treatment.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during Deflazacort therapy
Drug Interactions
Antidiabetic agents
May reduce the hypoglycemic effect of antidiabetic drugs, requiring dose adjustment.
Anticoagulants (e.g., warfarin)
May alter anticoagulant effects; monitor INR.
CYP3A4 Inducers (e.g., rifampin, phenytoin)
May decrease Deflazacort levels, reducing efficacy.
Diuretics (e.g., thiazides, loop diuretics)
Increased risk of hypokalemia.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Increased risk of gastrointestinal ulcers and bleeding.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May increase Deflazacort levels, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare. Symptoms may include an exaggeration of known side effects. Management is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Deflazacort is excreted in breast milk; advise caution or consider alternative feeding methods during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Ongoing clinical trials are evaluating Deflazacort's efficacy and safety in various indications, particularly in Duchenne Muscular Dystrophy, to optimize dosing and long-term outcomes.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (potassium, sodium)
- Bone mineral density (for long-term use)
- Growth monitoring in children
- Ophthalmological examinations (for long-term use, to check for cataracts/glaucoma)
Doctor Notes
- Emphasize the importance of gradual tapering to avoid adrenal crisis when discontinuing therapy.
- Monitor patients for signs of infection, hyperglycemia, and hypertension, especially during prolonged treatment.
- Consider co-administration of calcium and Vitamin D supplements for patients on long-term Deflazacort to mitigate bone loss.
- Educate patients about symptoms of adrenal insufficiency (e.g., severe fatigue, weakness, dizziness) and when to seek immediate medical attention.
Patient Guidelines
- Take Deflazit exactly as prescribed by your doctor.
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms or adrenal crisis.
- Report any new or worsening side effects to your healthcare provider.
- Avoid close contact with people who are sick or have infections, as corticosteroids can weaken your immune system.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Deflazit may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy, balanced diet, and limit sodium intake.
- Engage in regular, moderate exercise to help maintain bone density and muscle strength.
- Discuss with your doctor about calcium and Vitamin D supplementation, especially if on long-term therapy.
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