Deflazit
Generic Name
Deflazacort
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflazit 36 mg tablet | ৳ 34.00 | ৳ 340.00 |
Description
Overview of the medicine
Deflazacort is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used to treat various inflammatory and autoimmune conditions, including Duchenne muscular dystrophy.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition. For Duchenne muscular dystrophy, typical dosage is 0.9 to 1.5 mg/kg once daily. For other conditions, 6-18 mg once daily or as prescribed by a physician.
Elderly
No specific dose adjustment is generally required, but caution is advised due to increased susceptibility to side effects. Lower effective doses should be considered.
Renal_impairment
No dose adjustment is usually required for mild to moderate renal impairment. Caution is advised in severe renal impairment.
How to Take
Deflazit tablet should be taken orally, with or without food. It can be taken once daily. Do not crush or chew the tablet.
Mechanism of Action
Deflazacort acts by binding to specific glucocorticoid receptors within target cells, leading to changes in gene expression. This modulates the synthesis of proteins involved in inflammatory and immune responses, thereby exerting its anti-inflammatory and immunosuppressive effects.
Pharmacokinetics
Onset
Pharmacological effects typically begin within hours.
Excretion
Excreted mainly via urine (approximately 70%) and feces (approximately 30%).
Half life
The active metabolite has a plasma half-life of approximately 1.2 to 1.7 hours.
Absorption
Rapidly absorbed after oral administration and undergoes rapid conversion to its active metabolite, 21-desacetyl deflazacort.
Metabolism
Primarily metabolized in the liver to its active metabolite, 21-desacetyl deflazacort, which is responsible for most of its pharmacological activity.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any components of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Warfarin
Deflazacort may alter the anticoagulant effect of warfarin; close monitoring of INR is recommended.
Ketoconazole, Itraconazole
May increase plasma concentrations of deflazacort; dosage adjustment may be needed.
Rifampicin, Phenytoin, Carbamazepine
May decrease plasma concentrations of deflazacort; dosage adjustment may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggerated side effects like fluid retention, hypertension, and hyperglycemia. Management involves symptomatic and supportive treatment, including electrolyte balance correction and withdrawal of the drug.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; breastfeeding is not recommended during treatment. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any components of the formulation
- Administration of live or live-attenuated vaccines during treatment
Drug Interactions
Warfarin
Deflazacort may alter the anticoagulant effect of warfarin; close monitoring of INR is recommended.
Ketoconazole, Itraconazole
May increase plasma concentrations of deflazacort; dosage adjustment may be needed.
Rifampicin, Phenytoin, Carbamazepine
May decrease plasma concentrations of deflazacort; dosage adjustment may be needed.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggerated side effects like fluid retention, hypertension, and hyperglycemia. Management involves symptomatic and supportive treatment, including electrolyte balance correction and withdrawal of the drug.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; breastfeeding is not recommended during treatment. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Deflazacort has undergone extensive clinical trials, particularly for its efficacy and safety in Duchenne muscular dystrophy, demonstrating improved motor function and stabilization of disease progression.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Bone mineral density (with long-term use)
- Electrolyte levels
- Growth monitoring in children
Doctor Notes
- Emphasize the importance of gradual dose tapering before discontinuation.
- Monitor patients for signs of adrenal suppression and infection.
- Educate patients and caregivers about potential steroid side effects and when to seek medical attention.
Patient Guidelines
- Do not stop taking Deflazit abruptly; gradually reduce the dose under medical supervision.
- Report any unusual or severe side effects to your doctor immediately.
- Avoid contact with people who have infections (e.g., chickenpox, measles) while on this medication.
- Carry a steroid warning card.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Deflazacort may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise as advised by your doctor.
- Avoid excessive alcohol consumption and smoking.
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