Deflazit
Generic Name
Deflazacort
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| deflazit 6 mg suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Deflazit 6 mg Suspension contains Deflazacort, a glucocorticoid used for its anti-inflammatory and immunosuppressive effects. It is used to treat a variety of conditions including Duchenne muscular dystrophy, asthma, and rheumatic disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition. For severe inflammatory conditions, initial doses typically range from 6 mg to 18 mg per day, adjusted according to patient response. For Duchenne Muscular Dystrophy, approximately 0.9 mg/kg/day.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to increased susceptibility to side effects.
Renal_impairment
No specific dose adjustment is typically required, but use with caution in severe renal impairment.
How to Take
Deflazacort suspension should be taken orally, usually once daily. It can be taken with or without food, but taking it with food may help reduce gastrointestinal upset. Shake the bottle well before each use. Use the provided measuring device to ensure accurate dosing.
Mechanism of Action
Deflazacort is a synthetic glucocorticoid that binds to glucocorticoid receptors in the cytoplasm, leading to the formation of a hormone-receptor complex. This complex translocates to the nucleus, where it modulates the transcription of specific genes, resulting in anti-inflammatory and immunosuppressive effects. It reduces inflammation by inhibiting the release of inflammatory mediators and suppressing the migration of inflammatory cells.
Pharmacokinetics
Onset
Effects typically begin within hours to days, depending on the condition being treated.
Excretion
Mainly excreted via the kidneys (approximately 70%) and feces (approximately 30%).
Half life
The active metabolite has a plasma half-life of 1.1 to 1.9 hours.
Absorption
Rapidly absorbed orally and rapidly converted to the active metabolite, 21-desacetyl deflazacort.
Metabolism
Primarily metabolized in the liver by esterases to its active metabolite, 21-desacetyl deflazacort, which is then further metabolized.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment (unless benefits outweigh risks)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Vaccines
Avoid live or live-attenuated vaccines due to immunosuppression.
Antidiabetics
May decrease the hypoglycemic effect of antidiabetics, requiring dose adjustment.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin)
May decrease deflazacort levels, reducing efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase deflazacort levels, requiring dose adjustment.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare and unlikely to be life-threatening. Chronic overdose can lead to severe side effects such as adrenal suppression, Cushingoid features, and electrolyte imbalance. Treatment is symptomatic and supportive; gradual withdrawal may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Corticosteroids are excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment (unless benefits outweigh risks)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Vaccines
Avoid live or live-attenuated vaccines due to immunosuppression.
Antidiabetics
May decrease the hypoglycemic effect of antidiabetics, requiring dose adjustment.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin)
May decrease deflazacort levels, reducing efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir)
May increase deflazacort levels, requiring dose adjustment.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with corticosteroids is rare and unlikely to be life-threatening. Chronic overdose can lead to severe side effects such as adrenal suppression, Cushingoid features, and electrolyte imbalance. Treatment is symptomatic and supportive; gradual withdrawal may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Corticosteroids are excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months, refer to the package for exact expiry date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available
Clinical Trials
Deflazacort has undergone numerous clinical trials to establish its efficacy and safety in various indications, particularly in Duchenne muscular dystrophy, where it has shown benefits in preserving muscle strength and function.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (e.g., potassium)
- Blood pressure monitoring
- Bone mineral density (for long-term use)
- Growth monitoring in children
Doctor Notes
- Always consider the risk-benefit ratio for long-term corticosteroid therapy.
- Monitor patients for signs of adrenal suppression, especially during withdrawal.
- Educate patients on potential side effects and the importance of not discontinuing abruptly.
- Consider prophylactic measures for osteoporosis in long-term users.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to adrenal insufficiency.
- Report any signs of infection, such as fever or sore throat, to your doctor immediately.
- Follow a diet rich in calcium and vitamin D, and avoid excessive salt intake.
- Regularly monitor your blood sugar and blood pressure as advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Deflazacort may cause dizziness or blurred vision in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular, moderate exercise if possible.
- Avoid exposure to people with contagious diseases (e.g., chickenpox, measles).
- Limit alcohol consumption.
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