Denixil
Generic Name
Anxiosul (hypothetical benzodiazepine derivative)
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| denixil 05 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Denixil 0.5 mg Tablet is an anxiolytic medication used to treat anxiety disorders, panic disorder, and short-term insomnia. It works by calming the central nervous system.
Uses & Indications
Dosage
Adults
Initial dosage for adults is typically 0.25-0.5 mg, 1-2 times daily, titrated according to patient response and tolerability.
Elderly
Elderly patients should start with a lower initial dose, such as 0.25 mg once daily, due to increased sensitivity and slower elimination.
Renal_impairment
Dosage adjustment may be necessary in patients with renal impairment; use with caution and monitor closely.
How to Take
Denixil tablets should be taken orally, with or without food. Swallow the tablet whole with water; do not crush or chew.
Mechanism of Action
Denixil enhances the effect of the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, which leads to reduced neuronal excitability and produces a calming effect.
Pharmacokinetics
Onset
Onset of action typically within 30-60 minutes.
Excretion
Excreted mainly by the kidneys as metabolites.
Half life
Elimination half-life ranges from 18 to 50 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to Denixil or other benzodiazepines
- •Acute narrow-angle glaucoma
- •Severe respiratory insufficiency
- •Sleep apnea syndrome
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Anticonvulsants
May alter the plasma levels of other anticonvulsant drugs.
CYP3A4 Inhibitors
Drugs that inhibit CYP3A4 (e.g., ketoconazole, fluconazole, grapefruit juice) can increase Denixil plasma concentrations.
Alcohol and CNS Depressants
Potentiation of CNS depressant effects, leading to increased sedation and psychomotor impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, ataxia, diminished reflexes, and coma. Management is primarily supportive, involving monitoring of vital signs and maintaining airway. Flumazenil may be considered in severe cases but with caution.
Pregnancy & Lactation
Denixil is not recommended during pregnancy due to potential risks of fetal harm, including congenital malformations and neonatal withdrawal syndrome. It is also advised against during lactation as it can pass into breast milk and affect the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by Directorate General of Drug Administration (DGDA), Bangladesh
Patent Status
Patented
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Global Brand Names
International brand names for this medicine
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