Medicine Information

Dexifen

Name: Dexifen
Brand: Dexifen

Suspension100 mg/5 mlNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AE14

Generic Name

Dexibuprofen

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
dexifen 100 mg suspension	৳ 40.00	N/A

Description

Overview of the medicine

Dexibuprofen is the pharmacologically active S(+)-enantiomer of Ibuprofen, used for pain, inflammation, and fever. It offers similar efficacy to Ibuprofen but often at half the dose, with potentially fewer side effects. This suspension formulation is primarily for pediatric use.

Uses & Indications

Relief of mild to moderate pain (e.g., musculoskeletal pain, headache, dental pain)

Management of inflammation (e.g., juvenile arthritis, soft tissue injuries)

Reduction of fever (e.g., associated with colds, flu, or post-vaccination)

Dosage

Adults

Not typically indicated for adults in this 100 mg/5 ml suspension form. Adult doses of Dexibuprofen usually range from 200-400 mg 2-3 times daily, if needed in other formulations.

Elderly

Use with caution; lower doses may be required due to potential age-related renal or hepatic impairment. Monitor closely for adverse effects.

Children

For children, based on weight: 5-10 mg/kg body weight per dose, 3-4 times daily, not exceeding 30 mg/kg/day. Specific age/weight guidelines should be consulted.

Renal_impairment

Not recommended for severe renal impairment. Dose adjustment may be necessary for mild to moderate impairment; consult a physician.

How to Take

Dexifen suspension is for oral administration. Shake the bottle well before each use. It can be taken with food or milk to minimize gastrointestinal discomfort. Use the provided measuring spoon or oral syringe to ensure accurate dosing.

Mechanism of Action

Dexibuprofen inhibits prostaglandin synthesis by reversible inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation, pain, and fever.

Pharmacokinetics

Onset

Analgesic effect usually starts within 30 minutes after oral administration.

Excretion

Primarily excreted in the urine as inactive metabolites, with minimal unchanged drug excretion.

Half life

Approximately 1.8 to 3.5 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations are typically reached within 1-2 hours.

Metabolism

Extensively metabolized in the liver, mainly by hydroxylation and carboxylation to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to Dexibuprofen, Ibuprofen, aspirin, or other NSAIDs
Active peptic ulcer or a history of recurrent peptic ulcer/hemorrhage
Gastrointestinal bleeding or perforation related to previous NSAID therapy
Severe heart failure, severe renal impairment, or severe hepatic impairment
Last trimester of pregnancy (due to risk to fetus)

Drug Interactions

Lithium

Increased plasma lithium levels, potentially leading to toxicity.

Methotrexate

Increased plasma levels and toxicity of methotrexate.

Corticosteroids

Increased risk of gastrointestinal ulceration and bleeding.

Diuretics and ACE inhibitors

Reduced antihypertensive effect and increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Do not freeze. Keep out of sight and reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, dizziness, headache, tinnitus, and nystagmus. In severe cases, gastrointestinal bleeding, hypotension, acute renal failure, respiratory depression, and coma may occur. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered if recent ingestion.

Pregnancy & Lactation

Avoid in the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus and renal dysfunction. Use with caution in other trimesters only if clearly needed and under strict medical supervision. Small amounts of Dexibuprofen may be excreted in breast milk; use with caution during lactation, preferably consulting a physician.

Side Effects

Contraindications

Known hypersensitivity to Dexibuprofen, Ibuprofen, aspirin, or other NSAIDs
Active peptic ulcer or a history of recurrent peptic ulcer/hemorrhage
Gastrointestinal bleeding or perforation related to previous NSAID therapy
Severe heart failure, severe renal impairment, or severe hepatic impairment
Last trimester of pregnancy (due to risk to fetus)

Drug Interactions

Lithium

Increased plasma lithium levels, potentially leading to toxicity.

Methotrexate

Increased plasma levels and toxicity of methotrexate.

Corticosteroids

Increased risk of gastrointestinal ulceration and bleeding.

Diuretics and ACE inhibitors

Reduced antihypertensive effect and increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Do not freeze. Keep out of sight and reach of children.

Overdose

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml bottle100 ml bottle

Shelf Life

Typically 2-3 years from the date of manufacture. Refer to the specific product packaging for the exact expiry date.

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Generic available

Clinical Trials

Dexibuprofen has undergone extensive clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions, including pediatric uses. Comparative studies have shown similar efficacy to ibuprofen but with potentially a better tolerability profile.

Lab Monitoring

Renal function tests (e.g., serum creatinine, BUN) for long-term use or in patients with impaired renal function.
Liver function tests (e.g., ALT, AST) for long-term use or in patients with hepatic impairment.
Complete blood count (CBC) to monitor for anemia, especially with prolonged use.

Doctor Notes

Emphasize accurate dosing in pediatric patients using the provided measuring device to avoid under- or over-dosing.
Advise parents/caregivers to monitor for signs of gastrointestinal bleeding (e.g., black stools) and to seek immediate medical attention if these occur.
Caution against concurrent use with other NSAIDs or aspirin without medical advice.

Patient Guidelines

Always use the provided measuring device for accurate dosing.
Do not exceed the recommended dose or duration of treatment without consulting a doctor.
Report any unusual or severe symptoms, such as black or tarry stools, severe stomach pain, or persistent vomiting, immediately to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Dexifen may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should assess their reaction to the medicine before driving or operating machinery.

Lifestyle Advice

Ensure adequate hydration, especially when using during fever or in hot climates.
Avoid alcohol consumption while on Dexifen to reduce the risk of gastrointestinal side effects.
For chronic pain conditions, consider incorporating physiotherapy or gentle exercise as advised by a healthcare professional.