Dexifen
Generic Name
Dexibuprofen
Manufacturer
Opsonin Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexifen 200 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Dexifen 200 mg Tablet contains Dexibuprofen, which is the pharmacologically active S(+)-enantiomer of ibuprofen. It is used for the symptomatic treatment of pain and inflammation associated with various musculoskeletal and rheumatic disorders, dysmenorrhea, and dental pain.
Uses & Indications
Dosage
Adults
Initially 200 mg two to three times daily. May be increased to 300 mg three times daily if needed. Maximum daily dose 1200 mg.
Elderly
Use with caution; lower initial doses and careful monitoring for adverse effects, especially gastrointestinal bleeding and renal impairment.
Renal_impairment
Dose reduction necessary in patients with moderate to severe renal impairment (creatinine clearance < 50 mL/min). Not recommended for severe renal failure.
How to Take
Take orally, preferably with or after food, or with milk to minimize gastrointestinal discomfort. Do not chew or crush the tablet.
Mechanism of Action
Dexibuprofen exerts its therapeutic effects by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By inhibiting COX-1 and COX-2, dexibuprofen reduces prostaglandin production, thereby alleviating pain and inflammation.
Pharmacokinetics
Onset
Analgesic effect typically within 30 minutes to 1 hour.
Excretion
Mainly excreted in urine (approximately 90%) as metabolites and conjugates; some biliary excretion.
Half life
Approximately 1.8-3.5 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via hydroxylation and carboxylation to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to dexibuprofen, ibuprofen, aspirin or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking NSAIDs
Drug Interactions
Lithium
Increased plasma concentrations of lithium.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics and antihypertensives (e.g., ACE inhibitors)
Reduced efficacy of these drugs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Nausea, vomiting, abdominal pain, drowsiness, dizziness, tinnitus, headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, hepatic dysfunction, hypotension, bradycardia, tachycardia, and respiratory depression. Management: No specific antidote. Gastric lavage or activated charcoal may be considered within one hour of ingestion. Symptomatic and supportive treatment is necessary, monitoring vital signs and managing complications.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if clearly needed and the potential benefit outweighs the risk. Lactation: Excreted in small amounts into breast milk. Use with caution during breastfeeding, usually considered compatible with breastfeeding short-term.
Side Effects
Contraindications
- Hypersensitivity to dexibuprofen, ibuprofen, aspirin or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking NSAIDs
Drug Interactions
Lithium
Increased plasma concentrations of lithium.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics and antihypertensives (e.g., ACE inhibitors)
Reduced efficacy of these drugs.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Nausea, vomiting, abdominal pain, drowsiness, dizziness, tinnitus, headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, hepatic dysfunction, hypotension, bradycardia, tachycardia, and respiratory depression. Management: No specific antidote. Gastric lavage or activated charcoal may be considered within one hour of ingestion. Symptomatic and supportive treatment is necessary, monitoring vital signs and managing complications.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if clearly needed and the potential benefit outweighs the risk. Lactation: Excreted in small amounts into breast milk. Use with caution during breastfeeding, usually considered compatible with breastfeeding short-term.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture when stored correctly.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by health authorities (e.g., DGDA, EMA)
Patent Status
Generic (Off-patent)
Clinical Trials
Dexibuprofen has undergone various clinical trials demonstrating its efficacy and safety profile compared to ibuprofen and other NSAIDs for pain and inflammation management. Studies highlight its improved gastrointestinal tolerability due to being a single enantiomer.
Lab Monitoring
- Monitor complete blood count (CBC) if used long-term
- Monitor renal function (serum creatinine, BUN) periodically, especially in elderly or patients with pre-existing renal impairment
- Liver function tests (LFTs) in case of prolonged therapy or suspected hepatic dysfunction
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of GI bleeding and cardiovascular events.
- Assess renal function regularly, especially in patients with comorbidities or on concomitant medications affecting renal perfusion.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) immediately.
- Avoid alcohol consumption during treatment.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten one.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how dexibuprofen affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities that exacerbate pain during treatment.
- Regular exercise (if permitted by condition) can help manage chronic pain.
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