Dexifen
Generic Name
Dexibuprofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexifen 300 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Dexifen 300 mg Tablet is used to relieve pain and inflammation. It contains Dexibuprofen, an NSAID, which works by reducing substances in the body that cause pain and inflammation. It is effective for conditions like osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
The usual recommended dose is 300 mg two to three times daily. The maximum daily dose is 1200 mg. Doses should be adjusted according to the individual patient's response and tolerability.
Elderly
Lower doses may be required, and patients should be monitored for adverse effects. Initial dose should be 300 mg once or twice daily.
Renal_impairment
In mild to moderate renal impairment, dose reduction may be necessary. Dexibuprofen is contraindicated in severe renal impairment (creatinine clearance < 30 ml/min).
How to Take
Take the tablet orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not chew, crush, or break it.
Mechanism of Action
Dexibuprofen works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that mediate pain, inflammation, and fever. By reducing prostaglandin production, Dexibuprofen exerts its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect usually starts within 30 minutes to 1 hour.
Excretion
Excreted mainly via urine as metabolites, with a small amount excreted in feces.
Half life
The plasma elimination half-life is approximately 1.8-3.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached approximately 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver by oxidation (mainly via CYP2C9) and conjugation to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Dexibuprofen or any excipient, or to other NSAIDs (e.g., aspirin, ibuprofen)
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active or recurrent peptic ulcer/hemorrhage (two or more distinct episodes of ulceration or bleeding)
- Severe heart failure, severe renal failure, or severe hepatic failure
- Third trimester of pregnancy
- Cerebrovascular or other active bleeding
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced diuretic and antihypertensive effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, tinnitus, and metabolic acidosis. In severe cases, gastrointestinal bleeding, hypotension, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive. Gastric lavage and/or activated charcoal may be considered if ingested within 1 hour. Monitor vital signs and renal function.
Pregnancy & Lactation
Dexifen is contraindicated in the third trimester of pregnancy due to potential effects on fetal cardiovascular system (premature closure of the ductus arteriosus). Use during the first and second trimesters and during lactation should only be considered if the potential benefit outweighs the potential risk and under strict medical supervision. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Dexibuprofen or any excipient, or to other NSAIDs (e.g., aspirin, ibuprofen)
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active or recurrent peptic ulcer/hemorrhage (two or more distinct episodes of ulceration or bleeding)
- Severe heart failure, severe renal failure, or severe hepatic failure
- Third trimester of pregnancy
- Cerebrovascular or other active bleeding
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics and Antihypertensives
Reduced diuretic and antihypertensive effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, tinnitus, and metabolic acidosis. In severe cases, gastrointestinal bleeding, hypotension, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive. Gastric lavage and/or activated charcoal may be considered if ingested within 1 hour. Monitor vital signs and renal function.
Pregnancy & Lactation
Dexifen is contraindicated in the third trimester of pregnancy due to potential effects on fetal cardiovascular system (premature closure of the ductus arteriosus). Use during the first and second trimesters and during lactation should only be considered if the potential benefit outweighs the potential risk and under strict medical supervision. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies
Approval Status
DGDA approved
Patent Status
Off-patent for generic, brand protection varies
Clinical Trials
Dexibuprofen has been studied in numerous clinical trials demonstrating its efficacy and tolerability in various pain and inflammatory conditions, often showing a more favorable gastrointestinal tolerability profile compared to racemic ibuprofen due to its enantiomeric purity.
Lab Monitoring
- Complete Blood Count (CBC) periodically, especially during long-term therapy
- Renal function tests (e.g., serum creatinine, BUN) to monitor kidney health
- Liver function tests (e.g., ALT, AST) to assess liver health
- Stool for occult blood if gastrointestinal symptoms occur
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals to reduce the risk of cardiovascular and gastrointestinal adverse events.
- Monitor for signs and symptoms of GI bleeding (e.g., black stools, dyspepsia) and cardiovascular events (e.g., chest pain, shortness of breath) particularly in elderly patients or those with pre-existing conditions.
- Assess renal function periodically, especially in patients with impaired renal function or those receiving diuretics or ACE inhibitors.
Patient Guidelines
- Do not exceed the recommended dose or duration of treatment.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- Report any unusual bleeding, black/tarry stools, severe stomach pain, or yellowing of skin/eyes immediately.
- Avoid concurrent use of other NSAIDs without consulting a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Dexifen may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should be cautioned against driving or operating machinery if they experience these effects.
Lifestyle Advice
- Avoid or limit alcohol consumption while taking Dexifen, as it may increase the risk of stomach bleeding.
- Maintain adequate hydration, especially if you are elderly or have kidney problems.
- If you experience persistent stomach upset, consider taking the medicine with a meal or a glass of milk.
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