Dexifen
Generic Name
Dexibuprofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| dexifen 400 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Dexifen 400 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, dysmenorrhea, and dental pain. It works by blocking the production of certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
Usually 200 mg to 400 mg two to three times daily. Max 1200 mg/day. For chronic conditions, 400 mg once or twice daily.
Elderly
Start with the lowest effective dose and monitor for adverse effects. Dose adjustment might be necessary based on renal function.
Renal_impairment
Use with caution, reduced dosage may be necessary in severe renal impairment. Avoid if GFR < 30 mL/min.
How to Take
Take orally with water, preferably with or after food to minimize gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Dexibuprofen is the pharmacologically active S(+)-enantiomer of ibuprofen. It inhibits prostaglandin synthesis by reversibly blocking cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effect within 30 minutes.
Excretion
Excreted mainly in the urine (approximately 90%) as metabolites and their conjugates, with a small amount excreted in feces.
Half life
Approximately 1.8 to 3.5 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by oxidation and conjugation with glucuronic acid.
Side Effects
Contraindications
- Hypersensitivity to dexibuprofen or other NSAIDs
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Cerebrovascular or other active bleeding
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, drowsiness, dizziness, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, hepatic dysfunction, hypotension, and respiratory depression. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if clearly necessary and potential benefits outweigh risks. Small amounts may pass into breast milk; generally considered compatible with breastfeeding at low doses, but use with caution.
Side Effects
Contraindications
- Hypersensitivity to dexibuprofen or other NSAIDs
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Cerebrovascular or other active bleeding
Drug Interactions
SSRIs
Increased risk of GI bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Warfarin/Anticoagulants
Increased risk of bleeding.
Diuretics/ACE Inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, drowsiness, dizziness, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, hepatic dysfunction, hypotension, and respiratory depression. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if clearly necessary and potential benefits outweigh risks. Small amounts may pass into breast milk; generally considered compatible with breastfeeding at low doses, but use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., EMA, DGDA in Bangladesh)
Patent Status
Off-patent (generic versions available)
Clinical Trials
Extensive clinical trials have demonstrated its efficacy and safety in various pain and inflammatory conditions compared to placebo and other NSAIDs, showing a better gastrointestinal tolerability profile than racemic ibuprofen.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) periodically
- Liver function tests (e.g., AST, ALT) periodically
- Complete blood count (CBC) during long-term therapy
Doctor Notes
- Advise patients to take the lowest effective dose for the shortest possible duration.
- Monitor for signs of GI bleeding and cardiovascular events, especially in high-risk patients.
- Assess renal function regularly during long-term therapy.
Patient Guidelines
- Take with food or milk to prevent stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of stomach bleeding (e.g., black tarry stools).
- Avoid alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular, moderate exercise if appropriate for your condition.
- Avoid smoking.
- Limit alcohol intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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