Duracef
Generic Name
Cefadroxil
Manufacturer
Bristol-Myers Squibb (original discoverer); Various local manufacturers in Bangladesh
Country
USA (original discovery); Bangladesh (local manufacture)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| duracef 25 mg pediatric drop | ৳ 100.00 | N/A |
Description
Overview of the medicine
Cefadroxil is a first-generation cephalosporin antibiotic used to treat various bacterial infections, primarily in pediatric patients in this formulation.
Uses & Indications
Dosage
Adults
Not typically applicable for a pediatric drop formulation. Refer to other formulations for adult dosage (usually 1-2 grams daily).
Elderly
Not typically applicable for a pediatric drop formulation. Dosage adjustments may be needed for elderly with renal impairment if Cefadroxil is used in other forms.
Renal_impairment
Dosage adjustment is necessary in patients with renal impairment; dosage interval should be extended based on creatinine clearance. Consult a physician for specific guidelines.
How to Take
Administer orally, with or without food. Can be mixed with milk, formula, or fruit juice. Shake well before use. Use the provided dropper for accurate dosing.
Mechanism of Action
Cefadroxil inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Varies by infection, generally within a few hours to a day.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.
Half life
Approximately 1.5 hours in subjects with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract, even with food. Peak plasma concentrations are achieved in 1-2 hours.
Metabolism
Minimally metabolized.
Side Effects
Contraindications
- •Hypersensitivity to cefadroxil or other cephalosporins
- •History of severe hypersensitivity reactions to penicillin (due to potential cross-reactivity)
Drug Interactions
Probenecid
Increases cefadroxil levels by decreasing renal tubular secretion.
Aminoglycosides
Increased risk of nephrotoxicity with concomitant use.
Oral Anticoagulants
May potentiate the effects of anticoagulants (e.g., warfarin), requiring INR monitoring.
Storage
Store dry powder below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and rarely, neuromuscular excitability. Management is primarily supportive. Hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Pregnancy: Cefadroxil is classified as Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Lactation: Cefadroxil is excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years (refer to manufacturer's expiry date). Reconstituted suspension: 14 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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