Ema
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ema 20 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Ema 20 mg Tablet contains Esomeprazole, a proton pump inhibitor (PPI) used to treat conditions caused by excess stomach acid. It works by reducing the amount of acid your stomach makes, thereby alleviating symptoms of heartburn, acid reflux, and preventing ulcers.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily for 7-10 days (with antibiotics).
Elderly
No specific dosage adjustment needed, but monitor for adverse effects.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take one tablet orally, preferably one hour before a meal. Swallow whole with water; do not chew or crush.
Mechanism of Action
Esomeprazole inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby blocking the final step in acid production. This leads to a dose-dependent inhibition of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Approximately 80% via urine and 20% via feces as metabolites.
Half life
Approximately 1.5 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any PPI
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time
Clopidogrel
Reduced antiplatelet effect (avoid concomitant use)
Methotrexate
Increased methotrexate levels
Ketoconazole/Itraconazole
Decreased absorption due to increased gastric pH
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include drowsiness, tachycardia, and nausea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk, so use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole or any PPI
- Concomitant use with Nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time
Clopidogrel
Reduced antiplatelet effect (avoid concomitant use)
Methotrexate
Increased methotrexate levels
Ketoconazole/Itraconazole
Decreased absorption due to increased gastric pH
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include drowsiness, tachycardia, and nausea. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Excreted in breast milk, so use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Esomeprazole in the treatment of acid-related disorders.
Lab Monitoring
- Magnesium levels (for long-term use)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Advise patients to report any severe or persistent diarrhea.
- Consider calcium and vitamin D supplementation for long-term PPI users.
- Review need for continued PPI therapy periodically.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking abruptly.
- Inform your doctor about all medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty foods, caffeine).
- Eat smaller, more frequent meals.
- Elevate the head of your bed.
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Global Brand Names
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