Ema
Generic Name
Esomeprazole
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ema 40 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ema 40 mg capsule contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions caused by too much stomach acid.
Uses & Indications
Dosage
Adults
Typical dose is 20 mg or 40 mg once daily, depending on the condition. For erosive esophagitis, 20 mg or 40 mg once daily for 4 to 8 weeks. For GERD symptoms, 20 mg once daily for 4 weeks.
Elderly
No dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take the capsule whole with a glass of water, at least one hour before a meal. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically blocks the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, thereby inhibiting the final step of acid secretion.
Pharmacokinetics
Onset
Acid suppression begins within 1 hour, maximal effect within a few days of regular dosing.
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1.3 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- •Known hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased tacrolimus levels; monitor blood concentrations.
Clopidogrel
Reduced effectiveness of clopidogrel; consider alternative antiplatelet therapy.
Methotrexate
Increased methotrexate levels; monitor for toxicity.
Ketoconazole/Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with Esomeprazole overdose is very limited. Management should be symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. It is not known whether Esomeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the date of manufacture, specific to lot.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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