Medicine Information

Ema

Name: Ema
Brand: Ema

Tablet40 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Example Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ema 40 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Ema 40 mg tablet contains Esomeprazole, a proton pump inhibitor, used to treat conditions caused by excess stomach acid, such as GERD, stomach ulcers, and Zollinger-Ellison syndrome.

Uses & Indications

Treatment of gastroesophageal reflux disease (GERD)

Healing of erosive esophagitis

Maintenance of healing of erosive esophagitis

Treatment of duodenal ulcers associated with H. pylori

Prevention of NSAID-associated gastric ulcers

Zollinger-Ellison syndrome

Dosage

Adults

GERD: 20 mg or 40 mg once daily for 4-8 weeks. Erosive esophagitis: 40 mg once daily for 4-8 weeks. H. pylori eradication: 40 mg once daily with antibiotics.

Elderly

No dosage adjustment generally required, but caution is advised.

Renal_impairment

No dosage adjustment required.

How to Take

Take the tablet whole, at least one hour before a meal. Do not crush or chew.

Mechanism of Action

Esomeprazole is a proton pump inhibitor that reduces stomach acid secretion by irreversibly blocking the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells.

Pharmacokinetics

Onset

1 hour, full effect within 2-3 days.

Excretion

Mainly via urine (80%) and feces (20%).

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed, bioavailability approximately 90% after repeated dosing.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 system (CYP2C19 and CYP3A4).

Side Effects

Contraindications

Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR/prothrombin time; monitor closely.

Nelfinavir

Significant decrease in nelfinavir exposure; contraindicated.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.

Methotrexate

May increase methotrexate levels; consider temporary discontinuation of PPI.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms generally mild (e.g., drowsiness, tachycardia, nausea). Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, use with caution.

Side Effects

Contraindications

Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Increased INR/prothrombin time; monitor closely.

Nelfinavir

Significant decrease in nelfinavir exposure; contraindicated.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.

Methotrexate

May increase methotrexate levels; consider temporary discontinuation of PPI.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms generally mild (e.g., drowsiness, tachycardia, nausea). Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use in pregnancy only if clearly needed. Excretion into breast milk is unknown, use with caution.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10)30 tablets (3x10)

Shelf Life

36 months

Availability

Pharmacies, hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established its efficacy and safety profile for various acid-related disorders.

Lab Monitoring

Magnesium levels (with prolonged use)
Vitamin B12 levels (with prolonged use)
Bone mineral density (with prolonged high-dose use)

Doctor Notes

Advise patients to report any new or worsening symptoms.
Consider lowest effective dose for shortest duration.
Review need for continued PPI therapy periodically.

Patient Guidelines

Take as directed by your doctor.
Do not stop taking without consulting your doctor.
Report any severe or persistent side effects.
Take 30-60 minutes before food.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it's close to the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.