Ema
Generic Name
Esomeprazole 40 mg Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ema 40 mg injection | ৳ 85.00 | N/A |
Description
Overview of the medicine
Ema 40 mg Injection contains Esomeprazole, a proton pump inhibitor, used to treat conditions where there is too much acid in the stomach. It works by reducing the amount of acid produced.
Uses & Indications
Dosage
Adults
Typically 20 mg or 40 mg once daily via IV infusion over 10-30 minutes. Duration varies by indication.
Elderly
No specific dose adjustment required for elderly patients.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Administer intravenously as an injection over at least 3 minutes or as an infusion over 10 to 30 minutes. Do not administer by other routes.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Within 15-30 minutes after IV administration.
Excretion
Excreted primarily in urine (80%) and feces (20%) as metabolites.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after intravenous administration, reaching peak plasma concentrations within minutes.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to esomeprazole or any components of the formulation
- •Concomitant use with nelfinavir
Drug Interactions
Digoxin
May increase digoxin absorption and levels.
Warfarin
Monitor INR due to potential for increased bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel (due to CYP2C19 inhibition).
Methotrexate
May increase methotrexate levels, requiring dose adjustment.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Reconstituted solution should be used within 12 hours.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances, fatigue, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excretion into breast milk is unknown; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date when stored correctly.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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