Medicine Information

Ema

Name: Ema
Brand: Ema

Injection40 mgAnti-ulcerant, Proton Pump InhibitorATC: A02BC05

Generic Name

Esomeprazole 40 mg Injection

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
ema 40 mg injection	৳ 85.00	N/A

Description

Overview of the medicine

Ema 40 mg Injection contains Esomeprazole, a proton pump inhibitor, used to treat conditions where there is too much acid in the stomach. It works by reducing the amount of acid produced.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Healing of Gastric Ulcers

Zollinger-Ellison Syndrome

Prevention of NSAID-associated gastric ulcers

Dosage

Adults

Typically 20 mg or 40 mg once daily via IV infusion over 10-30 minutes. Duration varies by indication.

Elderly

No specific dose adjustment required for elderly patients.

Renal_impairment

No dose adjustment required for mild to moderate renal impairment. For severe impairment, caution is advised.

How to Take

Administer intravenously as an injection over at least 3 minutes or as an infusion over 10 to 30 minutes. Do not administer by other routes.

Mechanism of Action

Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.

Pharmacokinetics

Onset

Within 15-30 minutes after IV administration.

Excretion

Excreted primarily in urine (80%) and feces (20%) as metabolites.

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed after intravenous administration, reaching peak plasma concentrations within minutes.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole or any components of the formulation
Concomitant use with nelfinavir

Drug Interactions

Digoxin

May increase digoxin absorption and levels.

Warfarin

Monitor INR due to potential for increased bleeding risk.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel (due to CYP2C19 inhibition).

Methotrexate

May increase methotrexate levels, requiring dose adjustment.

Storage

Store below 30°C, protected from light and moisture. Do not freeze. Reconstituted solution should be used within 12 hours.

Overdose

Limited experience with overdose. Symptoms may include gastrointestinal disturbances, fatigue, and headache. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use during pregnancy only if clearly needed. Excretion into breast milk is unknown; caution advised during lactation.

Side Effects

Contraindications

Hypersensitivity to esomeprazole or any components of the formulation
Concomitant use with nelfinavir

Drug Interactions

Digoxin

May increase digoxin absorption and levels.

Warfarin

Monitor INR due to potential for increased bleeding risk.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel (due to CYP2C19 inhibition).

Methotrexate

May increase methotrexate levels, requiring dose adjustment.

Storage

Store below 30°C, protected from light and moisture. Do not freeze. Reconstituted solution should be used within 12 hours.

Overdose

Limited experience with overdose. Symptoms may include gastrointestinal disturbances, fatigue, and headache. Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use during pregnancy only if clearly needed. Excretion into breast milk is unknown; caution advised during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial of 40 mg with 1 ampoule of solvent

Shelf Life

Typically 24 to 36 months from manufacturing date when stored correctly.

Availability

Hospitals, Clinics, Pharmacies

Approval Status

Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)

Patent Status

Off-patent (generic versions available)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of Esomeprazole for various acid-related disorders, including short-term and long-term management of GERD, healing of ulcers, and Zollinger-Ellison Syndrome.

Lab Monitoring

Liver function tests (periodically during long-term therapy)
Magnesium levels (for prolonged use)
INR (if on warfarin)

Doctor Notes

Consider drug interactions, especially with Clopidogrel.
Monitor for hypomagnesemia in patients on prolonged therapy.
Advise patients on lifestyle modifications to complement therapy.

Patient Guidelines

Inform your doctor about all medications you are taking.
Report any unusual symptoms or severe side effects immediately.
Do not stop the medication without consulting your doctor.

Missed Dose Advice

If a dose is missed, administer it as soon as possible. If it's almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.