Enclot
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Reputable pharmaceutical companies (e.g., Square Pharmaceuticals Ltd., Beximco Pharmaceuticals Ltd. in Bangladesh)
Country
Global, commonly manufactured in various countries
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| enclot 650 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Enclot 650 mg Tablet contains Paracetamol, which is used to relieve mild to moderate pain and reduce fever. It works by inhibiting prostaglandin synthesis in the central nervous system.
Uses & Indications
Dosage
Adults
650 mg (1 tablet) every 4-6 hours as needed. Do not exceed 4000 mg (approximately 6 tablets of 650mg) in 24 hours. Some extended-release formulations may have different dosing.
Elderly
No specific dose adjustment for elderly patients, but caution is advised in those with pre-existing hepatic or renal impairment. Maximum daily dose should be observed.
Renal_impairment
Dose reduction or extended dosing intervals may be necessary for severe renal impairment (creatinine clearance <10 mL/min). Consult a physician.
How to Take
Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew if it is an extended-release formulation unless specified.
Mechanism of Action
Paracetamol primarily acts by inhibiting cyclooxygenase (COX) enzymes, mainly COX-2, in the central nervous system, thus reducing the synthesis of prostaglandins. Prostaglandins are mediators of pain and inflammation. Its antipyretic effect is due to its action on the hypothalamic heat-regulating center, leading to peripheral vasodilation and sweating.
Pharmacokinetics
Onset
Analgesic effect usually within 30-60 minutes; antipyretic effect within 30-60 minutes.
Excretion
Excreted mainly by the kidneys as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.
Half life
Plasma half-life is typically 1 to 4 hours; prolonged in hepatic dysfunction or overdose.
Absorption
Rapid and complete absorption from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 enzymes to a toxic intermediate (NAPQI), which is normally detoxified by conjugation with glutathione.
Side Effects
Contraindications
- •Hypersensitivity to Paracetamol or any other component of the formulation.
- •Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity, even at therapeutic doses of paracetamol, especially in chronic heavy drinkers.
Chloramphenicol
Paracetamol may increase the plasma concentration of chloramphenicol.
Warfarin and other coumarins
May increase the anticoagulant effect, leading to increased bleeding risk, especially with prolonged or high-dose use. Regular INR monitoring is advised.
Certain antiepileptic drugs (e.g., carbamazepine, phenytoin, phenobarbital)
May increase the risk of hepatotoxicity due to induction of paracetamol metabolizing enzymes.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating, which may appear within 24 hours. Severe overdose can lead to hepatotoxicity (liver damage), which may be delayed for 24-48 hours, and potentially cause acute liver failure, coma, and death. Management involves gastric lavage, activated charcoal, and administration of the antidote N-acetylcysteine (NAC) as soon as possible.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended therapeutic doses, making it a first-line choice for pain and fever. However, consult your doctor or pharmacist before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, specific to the manufacturer's guidelines.
Availability
Pharmacies, Drugstores
Approval Status
Generally approved by major health authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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