Medicine Information

Enclot

Name: Enclot
Brand: Enclot
Rating: 4.5 (117 reviews)

Tablet650 mgAnalgesic, AntipyreticATC: N02BE01

Generic Name

Paracetamol (Acetaminophen)

Manufacturer

Reputable pharmaceutical companies (e.g., Square Pharmaceuticals Ltd., Beximco Pharmaceuticals Ltd. in Bangladesh)

Country

Global, commonly manufactured in various countries

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
enclot 650 mg tablet	৳ 25.00	৳ 250.00

Description

Overview of the medicine

Enclot 650 mg Tablet contains Paracetamol, which is used to relieve mild to moderate pain and reduce fever. It works by inhibiting prostaglandin synthesis in the central nervous system.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, muscle ache, toothache, menstrual pain, backache, osteoarthritis pain)

Reduction of fever

Symptomatic relief of cold and flu

Dosage

Adults

650 mg (1 tablet) every 4-6 hours as needed. Do not exceed 4000 mg (approximately 6 tablets of 650mg) in 24 hours. Some extended-release formulations may have different dosing.

Elderly

No specific dose adjustment for elderly patients, but caution is advised in those with pre-existing hepatic or renal impairment. Maximum daily dose should be observed.

Renal_impairment

Dose reduction or extended dosing intervals may be necessary for severe renal impairment (creatinine clearance <10 mL/min). Consult a physician.

How to Take

Take orally with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew if it is an extended-release formulation unless specified.

Mechanism of Action

Paracetamol primarily acts by inhibiting cyclooxygenase (COX) enzymes, mainly COX-2, in the central nervous system, thus reducing the synthesis of prostaglandins. Prostaglandins are mediators of pain and inflammation. Its antipyretic effect is due to its action on the hypothalamic heat-regulating center, leading to peripheral vasodilation and sweating.

Pharmacokinetics

Onset

Analgesic effect usually within 30-60 minutes; antipyretic effect within 30-60 minutes.

Excretion

Excreted mainly by the kidneys as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.

Half life

Plasma half-life is typically 1 to 4 hours; prolonged in hepatic dysfunction or overdose.

Absorption

Rapid and complete absorption from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.

Metabolism

Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 enzymes to a toxic intermediate (NAPQI), which is normally detoxified by conjugation with glutathione.

Side Effects

Contraindications

Hypersensitivity to Paracetamol or any other component of the formulation.
Severe hepatic impairment or active liver disease.

Drug Interactions

Alcohol

Increases the risk of hepatotoxicity, even at therapeutic doses of paracetamol, especially in chronic heavy drinkers.

Chloramphenicol

Paracetamol may increase the plasma concentration of chloramphenicol.

Warfarin and other coumarins

May increase the anticoagulant effect, leading to increased bleeding risk, especially with prolonged or high-dose use. Regular INR monitoring is advised.

Certain antiepileptic drugs (e.g., carbamazepine, phenytoin, phenobarbital)

May increase the risk of hepatotoxicity due to induction of paracetamol metabolizing enzymes.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, abdominal pain, pallor, and sweating, which may appear within 24 hours. Severe overdose can lead to hepatotoxicity (liver damage), which may be delayed for 24-48 hours, and potentially cause acute liver failure, coma, and death. Management involves gastric lavage, activated charcoal, and administration of the antidote N-acetylcysteine (NAC) as soon as possible.

Pregnancy & Lactation

Paracetamol is generally considered safe for use during pregnancy and lactation at recommended therapeutic doses, making it a first-line choice for pain and fever. However, consult your doctor or pharmacist before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10 blister)50 tablets (5x10 blister)100 tablets (10x10 blister)

Shelf Life

2-3 years from the date of manufacture, specific to the manufacturer's guidelines.

Availability

Pharmacies, Drugstores

Approval Status

Generally approved by major health authorities (e.g., FDA, DGDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Paracetamol has undergone extensive clinical trials and has been in widespread use for decades, establishing its efficacy and safety profile for pain and fever management.

Lab Monitoring

Routine monitoring is not typically required for short-term use at recommended doses.
Liver function tests (ALT, AST, bilirubin) in cases of suspected overdose, prolonged high-dose therapy, or in patients with pre-existing hepatic impairment.
Renal function tests may be considered in patients with pre-existing renal impairment.

Doctor Notes

Emphasize the importance of not exceeding the maximum daily dose to prevent acetaminophen-induced hepatotoxicity.
Educate patients about hidden sources of paracetamol in combination products (e.g., cold and flu remedies).
Advise caution in patients with chronic alcohol use or pre-existing liver disease.

Patient Guidelines

Do not exceed the recommended dose to avoid serious liver damage.
Do not take with other medicines containing paracetamol.
Consult a doctor if pain or fever persists for more than a few days, or if new symptoms appear.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Enclot 650 mg Tablet is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities.

Lifestyle Advice

Stay well-hydrated, especially when experiencing fever.
Avoid or limit alcohol consumption while taking paracetamol, as it can increase the risk of liver damage.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Napa 650 mg (Beximco Pharmaceuticals Ltd.)Ace 650 mg (Square Pharmaceuticals Ltd.)Fevadol 650 mg (Incepta Pharmaceuticals Ltd.)Renova 650 mg (Opsonin Pharma Ltd.)