Eryzen
Generic Name
Erythromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eryzen 250 mg tablet | ৳ 4.38 | ৳ 26.28 |
| eryzen 500 mg tablet | ৳ 8.66 | ৳ 34.64 |
| eryzen 125 mg suspension | ৳ 57.00 | N/A |
Description
Overview of the medicine
Eryzen (Erythromycin) is a macrolide antibiotic used to treat various bacterial infections including respiratory tract infections, skin infections, and sexually transmitted infections.
Uses & Indications
Dosage
Adults
250 mg to 500 mg every 6-12 hours, depending on the infection severity and specific formulation. Max 4g/day.
Elderly
Similar to adult dosage; caution in patients with hepatic impairment.
Renal_impairment
Generally no dosage adjustment is needed in mild to moderate renal impairment. For severe impairment, dose reduction may be considered.
How to Take
Oral tablets/capsules can be taken with or without food depending on the specific salt form. Suspension should be shaken well before use.
Mechanism of Action
Erythromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide chains.
Pharmacokinetics
Onset
Typically within 1-2 hours for oral forms.
Excretion
Mainly through bile and feces; a small portion is excreted renally.
Half life
Approximately 1.5 to 2 hours.
Absorption
Oral absorption varies depending on the salt form; erythromycin base and stearate are best absorbed on an empty stomach, while erythromycin ethylsuccinate absorption is enhanced with food.
Metabolism
Primarily hepatic via cytochrome P450 3A4 (CYP3A4) enzymes.
Side Effects
Contraindications
- •Hypersensitivity to erythromycin or other macrolide antibiotics.
- •Co-administration with terfenadine, astemizole, cisapride, pimozide, or colchicine due to risk of serious cardiac arrhythmias and QT prolongation.
Drug Interactions
Digoxin
Increased serum digoxin levels, leading to toxicity.
Warfarin
Increased anticoagulant effect, leading to increased bleeding risk.
Theophylline
Increased serum theophylline levels, leading to toxicity.
Carbamazepine
Increased serum carbamazepine levels, leading to toxicity.
Statins (e.g., Simvastatin)
Increased risk of myopathy and rhabdomyolysis.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe gastrointestinal upset, hearing loss, and liver dysfunction. Treatment is symptomatic and supportive, including gastric lavage if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy and lactation, but use only if clearly needed and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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