Esogel
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esogel 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Esogel 40 mg Injection is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions like gastroesophageal reflux disease (GERD), ulcers, and other acid-related disorders.
Uses & Indications
Dosage
Adults
20-40 mg IV once daily, depending on the indication.
Elderly
No specific dose adjustment is usually required, but monitoring is advised.
Renal_impairment
No dose adjustment needed for renal impairment.
How to Take
This injection is administered intravenously by a healthcare professional.
Mechanism of Action
Esomeprazole irreversibly inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Rapid, within an hour.
Excretion
Mainly via urine (approx. 80%) and feces (approx. 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after intravenous administration, high bioavailability.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- •Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir.
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase INR.
Clopidogrel
May reduce antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels.
HIV Antivirals (e.g., Atazanavir, Nelfinavir)
May reduce absorption of these antivirals.
Storage
Store below 30°C, protect from light and moisture. Reconstituted solution has specific stability requirements.
Overdose
Symptoms are generally mild (gastric symptoms, lethargy). Supportive treatment is provided. No specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to manufacturer's label for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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