Esomiloc
Generic Name
Esomeprazole
Manufacturer
Specific manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esomiloc 20 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions caused by too much stomach acid.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily with antibiotics for 7-10 days.
Elderly
No dosage adjustment generally required.
Renal_impairment
No dosage adjustment required.
How to Take
Take one capsule whole with water at least one hour before a meal. Do not crush, chew, or open the capsule.
Mechanism of Action
Esomeprazole is the S-isomer of omeprazole. It acts by specifically inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step in gastric acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition occurs within 1 hour.
Excretion
Primarily excreted via urine (80%) and feces (20%).
Half life
Approximately 1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% (20 mg) and 89% (40 mg) after repeated once-daily dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR (International Normalized Ratio), monitor coagulation.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel, concurrent use not recommended.
Methotrexate
Increased methotrexate levels, monitor for toxicity.
Ketoconazole, Itraconazole
May decrease absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, and dry mouth. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excretion into breast milk is unknown; use with caution in lactating mothers.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR (International Normalized Ratio), monitor coagulation.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel, concurrent use not recommended.
Methotrexate
Increased methotrexate levels, monitor for toxicity.
Ketoconazole, Itraconazole
May decrease absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and may include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, and dry mouth. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excretion into breast milk is unknown; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders, including GERD, erosive esophagitis, and H. pylori eradication.
Lab Monitoring
- Monitor magnesium levels, especially with prolonged use (more than 3 months) or with concurrent use of diuretics.
- Monitor Vitamin B12 levels with prolonged use (more than 3 years) due to potential malabsorption.
- Monitor INR for patients on warfarin.
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary to achieve treatment goals.
- Assess for underlying conditions before prescribing for long-term management.
- Monitor patients on prolonged therapy for potential adverse effects such as hypomagnesemia or vitamin B12 deficiency.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor, even if you feel better.
- Report any new or worsening symptoms, or severe side effects to your doctor immediately.
- Capsules should be swallowed whole; do not crush, chew, or open them.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Esomeprazole may cause dizziness or blurred vision in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals and avoid eating just before bedtime.
- Elevate the head of your bed to help reduce nighttime reflux.
- Quit smoking and reduce alcohol intake, as these can worsen symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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