esomiloc
Generic Name
esomiloc-40-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esomiloc 40 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Esomiloc 40 mg Tablet is a proton pump inhibitor (PPI) used to reduce stomach acid production, treating conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD/Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: 40 mg twice daily, adjusted as needed. H. pylori eradication: 40 mg once daily with antibiotics for 10 days.
Elderly
No dosage adjustment generally required for elderly patients.
Renal_impairment
No dosage adjustment required for patients with renal impairment.
How to Take
Take orally, at least one hour before a meal. Swallow whole; do not crush, chew, or split the tablet.
Mechanism of Action
Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour.
Excretion
Excreted primarily through urine (80%) and feces (20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability is approximately 64% (for 40 mg dose), increasing with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any component of the formulation
- Hypersensitivity to other proton pump inhibitors
Drug Interactions
Digoxin
Increased absorption and plasma levels of digoxin.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced antiplatelet effect due to CYP2C19 inhibition.
Methotrexate
Increased plasma levels of methotrexate.
Atazanavir, Nelfinavir
Reduced plasma concentrations of antiretrovirals.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, nausea, sweating, flushing, headache, blurred vision. Management is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy only if clearly needed. Exercise caution when administered to a nursing mother due to potential for serious adverse reactions in breastfed infants.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any component of the formulation
- Hypersensitivity to other proton pump inhibitors
Drug Interactions
Digoxin
Increased absorption and plasma levels of digoxin.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Reduced antiplatelet effect due to CYP2C19 inhibition.
Methotrexate
Increased plasma levels of methotrexate.
Atazanavir, Nelfinavir
Reduced plasma concentrations of antiretrovirals.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, nausea, sweating, flushing, headache, blurred vision. Management is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy only if clearly needed. Exercise caution when administered to a nursing mother due to potential for serious adverse reactions in breastfed infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Expired for generic Esomeprazole
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials supporting its efficacy and safety for acid-related disorders.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Vitamin B12 levels (with prolonged use)
- Chromogranin A (CgA) levels (can be affected)
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Monitor for bone mineral density and magnesium levels in prolonged use.
- Rule out malignancy before initiating treatment for GERD.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly.
- Report any severe or persistent side effects.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy foods, caffeine, and alcohol to reduce acid reflux.
- Eat smaller, more frequent meals.
- Elevate the head of your bed.
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