Medicine Information

Esomiloc

Name: Esomiloc
Brand: Esomiloc
Rating: 4.5 (117 reviews)

Tablet20 mgProton Pump Inhibitor (PPI)ATC: A02BC05

Generic Name

Esomeprazole

Manufacturer

Aristopharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
esomiloc 20 mg tablet	৳ 6.00	৳ 60.00

Description

Overview of the medicine

Esomeprazole is a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.

Uses & Indications

Treatment of gastroesophageal reflux disease (GERD)

Healing of erosive esophagitis

Maintenance of healing of erosive esophagitis

Symptomatic GERD

Risk reduction of NSAID-associated gastric ulcers

Helicobacter pylori eradication (in combination with antibiotics)

Pathological hypersecretory conditions including Zollinger-Ellison syndrome

Dosage

Adults

Usually 20 mg or 40 mg once daily, depending on the indication. For GERD: 20-40 mg once daily for 4-8 weeks. For H. pylori: 20 mg twice daily for 10-14 days with antibiotics.

Elderly

No specific dosage adjustment is generally required for elderly patients, but caution is advised in those with severe hepatic impairment.

Renal_impairment

No dosage adjustment is required for patients with renal impairment.

How to Take

Take orally, at least one hour before a meal. Swallow the tablet whole; do not chew or crush it. If swallowing is difficult, the tablet can be dispersed in half a glass of non-carbonated water.

Mechanism of Action

Esomeprazole works by irreversibly blocking the H+/K+-ATPase pump (proton pump) located in the gastric parietal cells. This inhibition prevents the final step of acid production, thereby reducing both basal and stimulated gastric acid secretion.

Pharmacokinetics

Onset

Acid suppression starts within 1 hour.

Excretion

Metabolites are primarily excreted in the urine (approx 80%) and feces (approx 20%).

Half life

Approximately 1-1.5 hours.

Absorption

Rapidly absorbed after oral administration, peak plasma concentrations reached within 1-2 hours. Bioavailability is approximately 64% after a single dose and increases to 89% with repeated daily dosing.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 system, mainly by CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
Concomitant use with nelfinavir.

Drug Interactions

Warfarin

Monitor INR and prothrombin time; increased risk of bleeding.

Nelfinavir

Concomitant use is contraindicated due to significantly decreased nelfinavir plasma levels.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.

Methotrexate

Increased and prolonged serum levels of methotrexate, especially with high doses.

Diazepam, Citalopram, Phenytoin

Increased plasma concentrations of these drugs due to inhibition of CYP2C19.

Ketoconazole, Itraconazole, Erlotinib

Reduced absorption due to increased gastric pH.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

There is limited experience with esomeprazole overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment should be symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether esomeprazole is excreted in human milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets / strip30 tablets / box

Shelf Life

24 months from manufacturing date

Availability

Pharmacies, Hospitals

Approval Status

Approved (DGDA, Bangladesh)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have demonstrated esomeprazole's efficacy and safety in the treatment of GERD, erosive esophagitis, and other acid-related disorders across various patient populations.

Lab Monitoring

Magnesium levels (especially with long-term use, typically beyond 3 months).
Vitamin B12 levels (with prolonged use, as PPIs can impair absorption).
Bone mineral density (for very long-term use due to increased fracture risk).

Doctor Notes

Emphasize the importance of patient education regarding lifestyle modifications alongside medication.
Consider the lowest effective dose and shortest duration of PPI therapy, especially for long-term use.
Regularly assess the need for continued PPI therapy and screen for potential long-term adverse effects.

Patient Guidelines

Follow your doctor's instructions carefully regarding dosage and duration of treatment.
Do not stop taking the medicine abruptly, even if your symptoms improve, unless advised by your doctor.
Inform your doctor about all other medications, supplements, and herbal products you are taking.
Seek medical attention if you experience severe abdominal pain, persistent diarrhea, or any signs of an allergic reaction.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Esomeprazole generally does not impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or visual disturbances, you should avoid such activities.

Lifestyle Advice

Avoid foods and drinks that trigger heartburn or acid reflux, such as spicy foods, fatty foods, caffeine, and alcohol.
Eat smaller, more frequent meals instead of large ones.
Avoid lying down immediately after eating; wait at least 2-3 hours.
Maintain a healthy weight, as excess weight can worsen GERD symptoms.