Exephin 1 gm Injection is administered intravenously (IV) over 30 minutes, or as a deep intramuscular (IM) injection. The powder must be reconstituted with an appropriate diluent (e.g., Sterile Water for Injection, 0.9% Sodium Chloride Injection).

Cefepime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), leading to the disruption of cell wall integrity and ultimately bacterial cell lysis.

• •Known hypersensitivity to cefepime, any other cephalosporin antibiotic, penicillins, or any other beta-lactam antibiotic.
• •Patients with a history of severe immediate hypersensitivity reactions to beta-lactam antibiotics.

Store the dry powder at controlled room temperature (below 25°C) and protect from light. Reconstituted solutions should be used immediately or stored for a specified duration (e.g., 24 hours at room temperature or 7 days under refrigeration) as per manufacturer's instructions.

Symptoms of overdose may include encephalopathy, seizures, neuromuscular excitability. Management is symptomatic and supportive. Hemodialysis may be useful in facilitating the removal of cefepime from the body, especially in patients with impaired renal function.

Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefepime is excreted in breast milk in small amounts; use with caution in nursing mothers.