Administer intramuscularly (IM) or intravenously (IV) after reconstituting the powder with sterile water for injection. For IM, inject deeply into a large muscle mass. For IV, administer slowly over 3-5 minutes or as an infusion over 20-60 minutes.

Cefotaxime acts by inhibiting bacterial cell wall synthesis, leading to bactericidal effects. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall.

• •Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation.
• •History of severe hypersensitivity to any other beta-lactam antibiotic (e.g., penicillins).

Store the unconstituted powder at room temperature (below 30°C), protected from light and moisture. After reconstitution, use immediately or store as directed by the manufacturer (usually up to 24 hours at 2-8°C).

In case of overdose, symptoms may include exacerbation of side effects such as nausea, vomiting, diarrhea, and potentially neurological effects like convulsions, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis and peritoneal dialysis may aid in removal from the body.

Pregnancy Category B. Studies in animals have shown no evidence of fetal harm, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefotaxime is excreted in breast milk in low concentrations; use with caution in breastfeeding mothers.