For intravenous use, reconstitute with appropriate diluent and administer slowly over 30 minutes. For intramuscular use, reconstitute with Lidocaine 1% and administer deeply into a large muscle.

Ceftriaxone acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. This leads to the lysis of bacterial cells.

• •Hypersensitivity to ceftriaxone, any other cephalosporin, or penicillin
• •Neonates with hyperbilirubinemia
• •Concurrent use with calcium-containing intravenous solutions in neonates (≤28 days old)

Store below 30°C, protected from light and moisture. Reconstituted solutions should be used immediately or stored as per manufacturer's guidelines (e.g., up to 24 hours at 2-8°C).

Symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Management is primarily supportive; hemodialysis or peritoneal dialysis is generally not effective.

Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.