Adults

For mild to moderate infections: 500 mg/125 mg tablet every 8 hours. For severe infections: 875 mg/125 mg tablet every 12 hours. Duration depends on the infection severity.

Elderly

Dosage adjustment may be necessary in elderly patients with impaired renal function. Otherwise, adult dosage applies.

Renal_impairment

Creatinine clearance 10-30 mL/min: 500 mg/125 mg every 12 hours. Creatinine clearance < 10 mL/min: 500 mg/125 mg every 24 hours. Hemodialysis patients: 500 mg/125 mg every 24 hours, plus an additional dose during and at the end of dialysis.

Onset

Within 1 hour

Excretion

Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion). Small amounts are excreted in feces.

Half life

Approximately 1 to 1.5 hours for both components.

Absorption

Both Amoxicillin and Clavulanic Acid are well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations occurring approximately 1-2 hours after dosing. Food has minimal effect on absorption.

Metabolism

Amoxicillin is minimally metabolized. Clavulanic acid is extensively metabolized.

Probenecid

Decreases renal tubular secretion of Amoxicillin, leading to increased and prolonged blood levels of Amoxicillin. Concomitant use is not recommended.

Allopurinol

Increased incidence of skin rash.

Methotrexate

Increased toxicity of methotrexate due to decreased renal excretion. Monitor methotrexate levels.

Oral Anticoagulants

May prolong prothrombin time (INR). Careful monitoring is required.

Oral Contraceptives

May reduce the efficacy of oral contraceptives. Advise alternative or additional contraceptive methods.