G-Fix
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g fix 200 mg capsule | ৳ 45.00 | ৳ 180.00 |
| g fix 400 mg capsule | ৳ 60.00 | ৳ 420.00 |
| g fix 100 mg suspension | ৳ 230.00 | N/A |
Description
Overview of the medicine
G-Fix contains Cefixime, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, and ear.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing over 50 kg: 200-400 mg orally once daily or 200 mg twice daily. For uncomplicated gonorrhea, a single 400 mg dose is recommended.
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function. Close monitoring of renal function is advised.
Renal_impairment
For creatinine clearance 21-60 mL/min, 300 mg daily; for creatinine clearance <20 mL/min, 200 mg daily. Hemodialysis or peritoneal dialysis patients: 200 mg once daily.
How to Take
G-Fix can be taken with or without food. However, taking it with food may help reduce gastrointestinal upset.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. This leads to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in urine (about 50%) and bile (about 10%).
Half life
Average plasma half-life is 3-4 hours, allowing for once or twice daily dosing.
Absorption
Approximately 40-50% orally absorbed. Absorption may be slightly delayed by food but overall extent is not significantly affected.
Metabolism
Limited hepatic metabolism. Most of the absorbed drug is excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
Increased Cefixime bioavailability has been reported.
Probenecid
May increase Cefixime serum levels and prolong its half-life by decreasing renal tubular secretion.
Carbamazepine
Concurrent administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May prolong prothrombin time (INR), requiring close monitoring and possible dose adjustment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days, depending on formulation.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote for Cefixime. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk, so caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
Increased Cefixime bioavailability has been reported.
Probenecid
May increase Cefixime serum levels and prolong its half-life by decreasing renal tubular secretion.
Carbamazepine
Concurrent administration may increase carbamazepine plasma concentrations.
Warfarin and other anticoagulants
May prolong prothrombin time (INR), requiring close monitoring and possible dose adjustment.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days, depending on formulation.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote for Cefixime. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, Cefixime should be used during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the manufacturing date for tablets/capsules. Reconstituted suspension should be used within 7-14 days. Always refer to the specific expiry date on the packaging.
Availability
Available in pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic, patent expired
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials globally during its initial development. Bioequivalence studies have been conducted for generic formulations like G-Fix to ensure comparable efficacy and safety to the innovator product.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) should be monitored, especially in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) may be monitored during prolonged therapy.
- Liver function tests in patients with hepatic impairment.
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients and those with pre-existing renal impairment.
- Counsel patients on the importance of completing the full course of antibiotics to prevent resistance.
- Be aware of potential cross-reactivity with penicillin allergies and inquire about patient's allergy history.
Patient Guidelines
- Take G-Fix exactly as prescribed by your doctor.
- Complete the full course of antibiotics, even if you start to feel better, to prevent recurrence and development of resistance.
- Do not stop taking G-Fix without consulting your doctor.
- Inform your doctor about any unusual side effects or allergic reactions.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime usually has no effect on the ability to drive or operate machinery. However, if you experience side effects like dizziness or headache, avoid such activities until you feel well.
Lifestyle Advice
- Maintain good personal hygiene to help prevent infections.
- Drink plenty of fluids unless your doctor advises against it, especially if you experience diarrhea.
- Avoid alcohol consumption during the course of treatment, as it may worsen side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in G-Fix Brand
Other medicines available under the same brand name
