Initer
Generic Name
Human Chorionic Gonadotropin (hCG)
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| initer 10000 iu injection | ৳ 5,001.73 | N/A |
Description
Overview of the medicine
Human Chorionic Gonadotropin (hCG) is a hormone used for the treatment of various fertility-related conditions in both men and women, and for undescended testicles in pre-pubertal boys. It mimics the action of Luteinizing Hormone (LH).
Uses & Indications
Dosage
Adults
For ovulation induction: 5,000 to 10,000 IU given 1 day after the last dose of menotropin or follitropin. For male hypogonadism: 500 to 4,000 IU 2-3 times per week, often with menotropins.
Elderly
Dosage adjustments generally not necessary unless underlying renal/hepatic impairment is present. Careful monitoring recommended.
Renal_impairment
Use with caution; close monitoring of hormone levels may be required. Excretion may be impaired.
How to Take
Administer as an intramuscular (IM) or subcutaneous (SC) injection, as directed by a healthcare professional. Reconstitute the lyophilized powder with the provided diluent immediately prior to use.
Mechanism of Action
hCG binds to LH receptors on gonadal cells, stimulating the production of steroid hormones. In women, it triggers ovulation in anovulatory cycles and supports corpus luteum function. In men, it stimulates Leydig cells to produce testosterone and promotes spermatogenesis.
Pharmacokinetics
Onset
Effects on ovulation induction can be observed within hours. Spermatogenesis stimulation requires longer-term treatment.
Excretion
Mainly excreted in the urine.
Half life
Biphasic elimination with an initial half-life of 6-12 hours and a terminal half-life of 24-48 hours.
Absorption
Rapidly absorbed after intramuscular or subcutaneous injection. Peak plasma concentrations are typically reached within 6-16 hours.
Metabolism
Primarily metabolized in the kidneys and liver.
Side Effects
Contraindications
- Hypersensitivity to hCG or any excipients
- Precocious puberty (in males)
- Androgen-dependent tumors (e.g., prostate carcinoma, male breast cancer)
- Uncontrolled thyroid or adrenal dysfunction
- Primary ovarian failure
- Uterine fibroids, ovarian cysts or polycystic ovarian disease not due to primary ovarian failure
- Known or suspected sex-hormone dependent tumors
Drug Interactions
Gonadotropins (e.g., FSH, Menotropins)
Concurrent use with other gonadotropins is common in fertility treatments and requires careful monitoring to prevent excessive ovarian response (e.g., OHSS).
Storage
Store unopened vials at 2-25°C (refrigerated or room temperature, depending on specific product instructions). Protect from light. Do not freeze. Store reconstituted solution refrigerated (2-8°C) and use within the specified time frame.
Overdose
Overdose may lead to Ovarian Hyperstimulation Syndrome (OHSS) in women, which can be severe and life-threatening. Management is symptomatic and supportive, potentially requiring hospitalization. In men, excessive testicular stimulation may occur. Seek immediate medical attention.
Pregnancy & Lactation
Not indicated for therapeutic use during pregnancy. Use during lactation is generally not recommended as hCG may suppress milk production and is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to hCG or any excipients
- Precocious puberty (in males)
- Androgen-dependent tumors (e.g., prostate carcinoma, male breast cancer)
- Uncontrolled thyroid or adrenal dysfunction
- Primary ovarian failure
- Uterine fibroids, ovarian cysts or polycystic ovarian disease not due to primary ovarian failure
- Known or suspected sex-hormone dependent tumors
Drug Interactions
Gonadotropins (e.g., FSH, Menotropins)
Concurrent use with other gonadotropins is common in fertility treatments and requires careful monitoring to prevent excessive ovarian response (e.g., OHSS).
Storage
Store unopened vials at 2-25°C (refrigerated or room temperature, depending on specific product instructions). Protect from light. Do not freeze. Store reconstituted solution refrigerated (2-8°C) and use within the specified time frame.
Overdose
Overdose may lead to Ovarian Hyperstimulation Syndrome (OHSS) in women, which can be severe and life-threatening. Management is symptomatic and supportive, potentially requiring hospitalization. In men, excessive testicular stimulation may occur. Seek immediate medical attention.
Pregnancy & Lactation
Not indicated for therapeutic use during pregnancy. Use during lactation is generally not recommended as hCG may suppress milk production and is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened vials when stored as directed. Reconstituted solution has a shorter shelf life (e.g., 24 hours when refrigerated at 2-8°C).
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Human Chorionic Gonadotropin has been extensively studied in clinical trials for its approved indications over many decades, demonstrating established efficacy and safety profiles.
Lab Monitoring
- Serum estrogen levels (in women during ovarian stimulation)
- Ultrasound monitoring of ovarian follicles (in women)
- Serum testosterone levels (in men)
- Sperm count and motility (in men)
Doctor Notes
- Careful patient selection, dosage individualization, and close monitoring (hormone levels, ultrasound) are crucial, especially in fertility treatments, to maximize efficacy and minimize risks like OHSS.
- Educate patients thoroughly on the signs and symptoms of OHSS and emphasize the importance of seeking immediate medical attention if they occur.
- Ensure proper reconstitution and strict aseptic injection technique to prevent complications.
Patient Guidelines
- Follow your doctor's instructions precisely for dosage and administration.
- Report any severe abdominal pain, bloating, or difficulty breathing immediately.
- Store reconstituted solution as directed, typically refrigerated, and use within the specified time.
Missed Dose Advice
If a dose is missed, contact your doctor or pharmacist for advice. Do not take a double dose to make up for a missed one. Follow your prescribed schedule closely.
Driving Precautions
Initer-10000 IU Injection is not known to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or blurred vision, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet and lifestyle as advised by your healthcare provider.
- Avoid strenuous physical activity if symptoms of OHSS occur, and avoid intercourse if abdominal pain is present.
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