Initer
Generic Name
Interferon Alfa-2b
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| initer 3000 iu injection | ৳ 1,477.78 | N/A |
Description
Overview of the medicine
Interferon alfa-2b is a recombinant human interferon used to treat various conditions, including chronic hepatitis B and C, certain cancers, and condyloma acuminatum. It works by modulating the immune system and exhibiting antiproliferative and antiviral effects.
Uses & Indications
Dosage
Adults
Varies widely by indication. E.g., for chronic hepatitis C, 3 million IU three times a week via SC/IM injection.
Elderly
Dosage adjustments may be needed due to decreased renal function; careful monitoring recommended.
Renal_impairment
Dosage reduction may be necessary in severe renal impairment.
How to Take
Administer subcutaneously or intramuscularly. Reconstitute powder for injection with sterile water for injection if applicable. Ensure proper aseptic technique.
Mechanism of Action
Binds to specific receptors on cell surfaces, initiating a complex intracellular signaling cascade that leads to the transcription of specific genes. These gene products mediate the antiviral, antiproliferative, and immunomodulatory effects of interferons.
Pharmacokinetics
Onset
Varies depending on condition, but antiviral effects can begin within hours.
Excretion
Primarily renal excretion of metabolites.
Half life
Approximately 2-4 hours after IV, 3-8 hours after IM/SC.
Absorption
High bioavailability after subcutaneous/intramuscular injection (>80%). Peak serum levels achieved within 3-12 hours.
Metabolism
Primarily renal and hepatic catabolism, filtered and reabsorbed by the kidney.
Side Effects
Contraindications
- Hypersensitivity to interferon alfa-2b or any component of the formulation.
- Autoimmune hepatitis or decompensated liver disease.
- History of severe pre-existing cardiac disease.
- Uncontrolled seizure disorders.
- Concomitant use with telbivudine (for chronic hepatitis B).
Drug Interactions
Zidovudine
Increased hematologic toxicity.
Theophylline
May increase theophylline levels; monitor.
Immunosuppressants
Increased risk of infection.
Myelosuppressive agents
Increased risk of myelosuppression.
Storage
Store at 2-8°C (refrigerate). Do not freeze. Protect from light.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Lactation: Excreted in human milk; use with caution.
Side Effects
Contraindications
- Hypersensitivity to interferon alfa-2b or any component of the formulation.
- Autoimmune hepatitis or decompensated liver disease.
- History of severe pre-existing cardiac disease.
- Uncontrolled seizure disorders.
- Concomitant use with telbivudine (for chronic hepatitis B).
Drug Interactions
Zidovudine
Increased hematologic toxicity.
Theophylline
May increase theophylline levels; monitor.
Immunosuppressants
Increased risk of infection.
Myelosuppressive agents
Increased risk of myelosuppression.
Storage
Store at 2-8°C (refrigerate). Do not freeze. Protect from light.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Lactation: Excreted in human milk; use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies and hospitals
Approval Status
Approved by DGDA and FDA
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various indications, including chronic hepatitis and certain malignancies.
Lab Monitoring
- Complete Blood Count (CBC) with differential
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Thyroid Function Tests (TFTs)
- Electrolytes
Doctor Notes
- Monitor CBC, LFT, RFT, and TFT regularly.
- Assess for neuropsychiatric symptoms before and during treatment.
- Educate patients about potential flu-like symptoms and management strategies.
Patient Guidelines
- Do not discontinue treatment without consulting your doctor.
- Report any signs of depression or unusual behavior immediately.
- Maintain adequate hydration.
- Learn proper injection technique if self-administering.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause fatigue, dizziness, or confusion; caution advised when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, especially if treating hepatitis.
- Practice good hygiene to prevent infections.
- Ensure proper nutrition and rest.
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