Initer
Generic Name
Epoetin Alfa 2000 IU
Manufacturer
Reputable Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| initer 2000 iu injection | ৳ 1,136.75 | N/A |
Description
Overview of the medicine
Initer 2000 IU Injection contains Epoetin Alfa, a recombinant human erythropoietin, used to stimulate red blood cell production in patients with anemia due to chronic kidney disease, chemotherapy, or certain surgical procedures.
Uses & Indications
Dosage
Adults
CKD: Initial dose 50-100 IU/kg 3 times a week (IV/SC). Adjust based on hemoglobin response. Chemotherapy-induced anemia: 150 IU/kg 3 times a week (SC) or 40,000 IU once weekly (SC).
Elderly
No specific dose adjustment for elderly patients, but careful monitoring is advised due to potential comorbidities.
Renal_impairment
The primary indication is for anemia in chronic renal failure; dosage is adjusted to achieve target hemoglobin levels.
How to Take
Administer intravenously or subcutaneously. Do not shake the vial. The solution should be clear and colorless.
Mechanism of Action
Epoetin Alfa is a glycoprotein that stimulates erythropoiesis by binding to the erythropoietin receptor on erythroid progenitor cells, leading to their proliferation and differentiation into mature red blood cells.
Pharmacokinetics
Onset
Hemoglobin levels begin to rise within 2-6 weeks.
Excretion
Mainly through the reticuloendothelial system; minimal renal excretion.
Half life
Approximately 4-13 hours after intravenous administration; slightly longer after subcutaneous administration (13-24 hours).
Absorption
Bioavailability is 31-61% after subcutaneous administration. Intravenous administration provides immediate and complete bioavailability.
Metabolism
Primarily cleared by erythroid precursor cells.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure Red Cell Aplasia (PRCA) unrelated to erythropoietin.
- Known hypersensitivity to Epoetin Alfa or any excipients.
Drug Interactions
Cyclosporine
May require increased cyclosporine dose due to decreased blood levels.
Iron supplements
Essential for optimal response; inadequate iron can limit efficacy.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light.
Overdose
Overdose can lead to symptoms of polycythemia (e.g., increased blood viscosity). Management includes phlebotomy if clinically indicated.
Pregnancy & Lactation
Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored correctly.
Availability
Hospitals, Clinics, and Pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials support the efficacy and safety of Epoetin Alfa in various anemic conditions.
Lab Monitoring
- Hemoglobin and hematocrit levels
- Iron status (ferritin, transferrin saturation)
- Blood pressure monitoring
Doctor Notes
- Monitor hemoglobin levels closely and adjust dose to avoid exceeding 11 g/dL.
- Assess iron stores before and during treatment.
- Educate patients on symptoms of thrombosis.
Patient Guidelines
- Do not discontinue treatment without consulting your doctor.
- Report any sudden increase in blood pressure or signs of clotting.
- Ensure adequate iron intake as prescribed by your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. Do not double the next dose. Consult your doctor for further instructions.
Driving Precautions
No specific restrictions on driving or operating machinery, but if you experience dizziness or seizures, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in moderate physical activity as advised by your doctor.
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Global Brand Names
International brand names for this medicine
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