Adults

1 drop in the affected eye(s) 3 times daily for 7 days, or as directed by physician.

Elderly

No specific dose adjustment required for elderly patients.

Renal_impairment

No specific dose adjustment required for renal impairment, as systemic absorption is minimal.

Onset

Clinical improvement often observed within 2-3 days of treatment.

Excretion

Primarily excreted unchanged via urine if any systemic absorption occurs; however, most of the topically applied drug is cleared locally or through tear drainage.

Half life

Not well characterized for topical ophthalmic use due to minimal systemic absorption, but active drug concentrations persist in ocular tissues for several hours.

Absorption

Minimal systemic absorption occurs following topical ocular administration. Local concentrations in ocular tissues are significantly higher than plasma levels.

Metabolism

Limited systemic metabolism due to minimal absorption. Likely metabolized in the liver if systemically absorbed, but this is negligible for topical application.

Systemic fluoroquinolones

Minimal systemic absorption, so interactions with systemic drugs are unlikely.

Other topical ophthalmic medications

Allow at least 5 minutes between applying different eye drops.