Administer intramuscularly (IM) slowly and deeply into a large muscle or intravenously (IV) as a bolus over at least 15 seconds. Should not be given epidurally or intrathecally. Maximum duration of treatment should not exceed 5 days.

Ketorolac works by inhibiting the synthesis of prostaglandins by blocking cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin levels, Ketorolac provides analgesic, anti-inflammatory, and antipyretic effects.

• •Hypersensitivity to ketorolac, aspirin, or other NSAIDs.
• •Active peptic ulcer disease, recent gastrointestinal bleeding or perforation.
• •Advanced renal impairment or at risk of renal failure due to volume depletion.
• •History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs.
• •Concomitant use with other NSAIDs, aspirin, or anticoagulants.
• •Cerebrovascular bleeding or suspected bleeding.
• •Prophylactic use before major surgery due to inhibition of platelet function.
• •Pregnancy (especially third trimester) and lactation.

Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, and drowsiness. Rare cases of gastrointestinal bleeding, hypertension, acute renal failure, and respiratory depression may occur. Management is symptomatic and supportive. No specific antidote exists. Gastric lavage and activated charcoal may be considered if oral overdose.

Pregnancy Category C (D in third trimester): Not recommended during pregnancy, especially in the third trimester due to potential premature closure of the fetal ductus arteriosus and effects on labor. Lactation: Small amounts are excreted in breast milk; therefore, it is not recommended during breastfeeding.