Ketromin
Generic Name
Ketorolac Tromethamine 30 mg injection
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketromin 30 mg injection | ৳ 60.00 | N/A |
Description
Overview of the medicine
Ketorolac Tromethamine is a potent non-steroidal anti-inflammatory drug (NSAID) primarily used for the short-term management of moderate to severe acute pain, typically for post-operative pain.
Uses & Indications
Dosage
Adults
Single IM/IV dose: 30 mg. Multiple IM/IV doses: 30 mg every 6 hours, not exceeding 120 mg/day. Max duration 5 days.
Elderly
Lower doses are recommended, typically 15 mg every 6 hours IM/IV, not exceeding 60 mg/day. Max duration 5 days.
Renal_impairment
Contraindicated in advanced renal impairment. For mild to moderate impairment (creatinine clearance 30-60 mL/min), dose reduction to 15 mg every 6 hours, not exceeding 60 mg/day.
How to Take
For intramuscular (IM) injection, administer slowly and deeply into a large muscle. For intravenous (IV) injection, administer slowly over at least 15 seconds.
Mechanism of Action
It inhibits prostaglandin synthesis by blocking the cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesia usually begins within 30 minutes after IM or IV administration.
Excretion
Primarily renal (approximately 90% as metabolites and unchanged drug), with a small amount excreted in feces.
Half life
Approximately 5-6 hours in healthy adults; may be prolonged in elderly or renally impaired patients.
Absorption
Rapidly and completely absorbed after intramuscular administration; peak plasma concentrations achieved within 30-60 minutes. Bioavailability is 100%.
Metabolism
Primarily hepatic, via hydroxylation and conjugation with glucuronic acid.
Side Effects
Contraindications
- •Hypersensitivity to ketorolac or other NSAIDs (e.g., aspirin-induced asthma)
- •Active peptic ulcer disease, recent gastrointestinal bleeding or perforation
- •Advanced renal impairment or risk of renal failure
- •Coagulation disorders or patients on anticoagulants
- •Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- •Concomitant use with other NSAIDs, aspirin, probenecid, or pentoxifylline
- •Pregnancy (especially third trimester) and labor/delivery
Drug Interactions
Lithium
Increased plasma lithium levels and potential toxicity.
Probenecid
Reduced ketorolac clearance, leading to increased plasma levels and half-life.
Methotrexate
Increased methotrexate toxicity.
Pentoxifylline
Increased risk of bleeding.
ACE Inhibitors / ARBs
Increased risk of renal impairment, especially in dehydrated patients.
Other NSAIDs / Aspirin
Increased risk of GI side effects and bleeding.
Diuretics (e.g., Furosemide)
Reduced natriuretic effect of diuretics.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, and drowsiness. Rare cases of gastrointestinal bleeding, acute renal failure, and respiratory depression have been reported. Management is supportive and symptomatic.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use during lactation should be with caution as ketorolac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date when stored under recommended conditions.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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