Lepsytam
Generic Name
Levetiracetam 250 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lepsytam 250 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Lepsytam 250 mg Tablet contains Levetiracetam, an antiepileptic medicine used to treat various types of seizures, including partial onset seizures, myoclonic seizures, and primary generalized tonic-clonic seizures.
Uses & Indications
Dosage
Adults
Initial dose: 500 mg twice daily. May increase by 500 mg twice daily every 2 weeks to a maximum of 1500 mg twice daily, based on clinical response and tolerability.
Elderly
Initial dose may be lower, typically 500 mg twice daily, and adjusted based on renal function and tolerability.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl < 80 mL/min, lower doses are recommended (e.g., CrCl 50-79 mL/min: 500-1000 mg twice daily; CrCl 30-49 mL/min: 250-750 mg twice daily).
How to Take
Take Lepsytam 250 mg Tablet orally, with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
The precise mechanism by which levetiracetam exerts its antiepileptic effect is unknown. However, it is thought to modulate synaptic neurotransmission by binding to synaptic vesicle protein 2A (SV2A) in the brain, thereby inhibiting excessive neuronal firing.
Pharmacokinetics
Onset
Within hours of administration, full therapeutic effect may take several days.
Excretion
Excreted primarily via the kidneys, with about 66% of a dose excreted unchanged in urine.
Half life
Approximately 7 hours in healthy adults; about 10-11 hours in elderly.
Absorption
Rapidly and almost completely absorbed after oral administration, peak plasma concentrations typically occur within 1.3 hours. Bioavailability is nearly 100%.
Metabolism
Limited metabolism in humans, primarily by enzymatic hydrolysis of the acetamide group; not extensively metabolized by hepatic cytochrome P450 isoenzymes.
Side Effects
Contraindications
- •Hypersensitivity to levetiracetam or any component of the formulation
- •Known allergic reaction to pyrrolidone derivatives
Drug Interactions
Methotrexate
Co-administration with methotrexate may decrease methotrexate clearance, leading to increased methotrexate concentrations and potential toxicity. Monitor methotrexate levels.
Other antiepileptic drugs
Generally, levetiracetam has minimal drug-drug interactions. It does not significantly interact with other AEDs like phenytoin, carbamazepine, valproate, or phenobarbital.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, agitation, aggression, decreased level of consciousness, respiratory depression, and coma. Treatment is supportive and may include gastric lavage immediately after ingestion and observation. Hemodialysis can remove levetiracetam.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Levetiracetam is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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