Lepsytam
Generic Name
Levetiracetam 500 mg Injection
Manufacturer
Reputable Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lepsytam 500 mg injection | ৳ 40.00 | N/A |
Description
Overview of the medicine
Lepsytam 500 mg Injection is an antiepileptic drug containing Levetiracetam, used for the treatment of various types of seizures including partial-onset seizures, myoclonic seizures in juvenile myoclonic epilepsy, and primary generalized tonic-clonic seizures. It is administered intravenously, especially when oral administration is temporarily not feasible.
Uses & Indications
Dosage
Adults
Initial dose is typically 500 mg twice daily. The daily dose may be increased by 500 mg twice daily every 2 weeks to a maximum of 1500 mg twice daily. The IV dose is usually the same as the oral dose.
Elderly
No specific dose adjustment based solely on age, but consider renal function.
Renal_impairment
Dosage adjustment is necessary in patients with impaired renal function, based on creatinine clearance. For example, CrCl 50-79 mL/min: 500-1000 mg twice daily; CrCl 30-49 mL/min: 250-750 mg twice daily; CrCl <30 mL/min: 250-500 mg twice daily. Hemodialysis patients require an additional post-dialysis dose.
How to Take
Lepsytam 500 mg Injection is for intravenous administration only. It should be diluted in a compatible diluent (e.g., 0.9% sodium chloride injection, Lactated Ringer's injection, Dextrose 5% injection) and infused intravenously over 15 minutes.
Mechanism of Action
The exact mechanism of action of Levetiracetam is not fully understood, but it is believed to involve binding to the synaptic vesicle protein 2A (SV2A) in the brain, which is thought to modulate neurotransmitter release and thus exert its antiepileptic effects.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV administration.
Excretion
Primarily renal; about 66% of a dose is excreted unchanged in urine within 48 hours.
Half life
Approximately 6-8 hours in adults, shorter (4-6 hours) in children, and prolonged in renal impairment.
Absorption
Rapid and complete absorption after oral administration; IV administration bypasses absorption, leading to 100% bioavailability.
Metabolism
Not extensively metabolized in the liver; the primary metabolic pathway is enzymatic hydrolysis of the acetamide group, which is not cytochrome P450-dependent.
Side Effects
Contraindications
- •Hypersensitivity to Levetiracetam or any component of the formulation.
Drug Interactions
Methotrexate
Decreased renal clearance of methotrexate, potentially leading to increased methotrexate concentrations and toxicity. Monitor methotrexate levels.
Central Nervous System Depressants
May enhance CNS depressant effects when used concomitantly with alcohol or other CNS depressants.
Storage
Store at room temperature (20°C to 25°C), protected from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma. Management is supportive, including observation of vital signs and clinical status. There is no specific antidote; hemodialysis can be effective in removing the drug from the system.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Levetiracetam is excreted in human milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture when stored correctly.
Availability
Hospitals, retail pharmacies
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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