Lyric
Generic Name
Pregabalin
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lyric 150 mg capsule | ৳ 30.00 | ৳ 180.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain agent used to treat various conditions including neuropathic pain, fibromyalgia, generalized anxiety disorder, and as an adjunctive therapy for partial-onset seizures.
Uses & Indications
Dosage
Adults
Typical starting dose is 75 mg twice daily or 50 mg three times daily. May be increased to 150 mg twice daily or 100 mg three times daily within a week, based on response and tolerability. Maximum dose usually 600 mg/day.
Elderly
Dosage adjustment may be necessary in elderly patients with reduced renal function. Start with a lower dose.
Renal_impairment
Dosage must be adjusted based on creatinine clearance (CrCl). For CrCl 30-60 mL/min, maximum dose 300 mg/day; for CrCl 15-30 mL/min, maximum dose 150 mg/day; for CrCl <15 mL/min, maximum dose 75 mg/day. Hemodialysis patients require a supplementary dose after each dialysis session.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta (α2δ) subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters, including glutamate, noradrenaline, and substance P. This action is thought to stabilize hyperexcited neurons and reduce nerve pain signals.
Pharmacokinetics
Onset
Analgesic effects typically within 1 week for neuropathic pain; anxiolytic effects within 1 week.
Excretion
Excreted primarily unchanged in the urine; renal excretion is the major route of elimination.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1.5 hours. Bioavailability is ≥90% and is independent of dose.
Metabolism
Negligible hepatic metabolism; not significantly metabolized in humans.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe respiratory depression (rare, but increased risk with concomitant CNS depressants).
Drug Interactions
CNS Depressants (e.g., Opioids, Benzodiazepines, Alcohol)
Increased risk of additive central nervous system depression, leading to sedation, respiratory depression, and coma. Use with caution.
Thiazolidinedione Antidiabetic Agents (e.g., Rosiglitazone, Pioglitazone)
May enhance weight gain and peripheral edema when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is primarily supportive. Hemodialysis can effectively remove pregabalin from plasma if needed for severe overdose.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe respiratory depression (rare, but increased risk with concomitant CNS depressants).
Drug Interactions
CNS Depressants (e.g., Opioids, Benzodiazepines, Alcohol)
Increased risk of additive central nervous system depression, leading to sedation, respiratory depression, and coma. Use with caution.
Thiazolidinedione Antidiabetic Agents (e.g., Rosiglitazone, Pioglitazone)
May enhance weight gain and peripheral edema when co-administered.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is primarily supportive. Hemodialysis can effectively remove pregabalin from plasma if needed for severe overdose.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA, EMA, DGDA
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated Pregabalin's efficacy and safety for its approved indications. Studies typically involve randomized, placebo-controlled trials across various patient populations.
Lab Monitoring
- Monitor renal function periodically, especially in elderly patients or those with pre-existing renal impairment.
- Monitor weight, as significant weight gain can occur.
- Observe for changes in mental status or emergence of suicidal thoughts/behavior.
Doctor Notes
- Advise patients about potential CNS depression and avoid co-administration with other CNS depressants.
- Counsel patients on the importance of gradual tapering to prevent withdrawal symptoms.
- Monitor for signs of suicidal ideation and advise patients/caregivers to report any mood changes.
Patient Guidelines
- Do not discontinue Pregabalin abruptly; it should be tapered gradually over at least 1 week to avoid withdrawal symptoms.
- Avoid alcohol and other CNS depressants while taking this medicine.
- Report any changes in mood, behavior, or suicidal thoughts to your doctor immediately.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabalin may cause dizziness, drowsiness, and blurred vision. Patients should be advised not to drive or operate complex machinery until they are reasonably certain that pregabalin does not adversely affect their ability to perform such activities.
Lifestyle Advice
- For chronic pain, incorporate regular, gentle exercise and stress management techniques.
- Maintain a balanced diet to manage potential weight gain.
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