Lyric
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lyric 75 mg capsule | ৳ 19.00 | ৳ 190.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain agent used to treat neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia), fibromyalgia, and as adjunctive therapy for partial onset seizures in adults.
Uses & Indications
Dosage
Adults
Initial dose 75 mg twice daily or 50 mg three times daily (150 mg/day). May be increased gradually up to 150-600 mg/day in divided doses, depending on indication and patient response.
Elderly
Lower doses may be required due to age-related decrease in renal function. Start with 25-50 mg daily and titrate slowly.
Renal_impairment
Dose adjustment necessary based on creatinine clearance. For creatinine clearance <30 mL/min, dose should be reduced significantly.
How to Take
Lyric capsules should be taken orally with or without food. Swallow the capsule whole with water.
Mechanism of Action
Pregabalin binds with high affinity to the alpha-2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system, which is thought to modulate the release of several excitatory neurotransmitters.
Pharmacokinetics
Onset
Variable; pain relief can start within a week, but full therapeutic effect may take several weeks.
Excretion
Primarily excreted unchanged in the urine; renal elimination is the major route of excretion.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations usually occur within 1 hour. Oral bioavailability is >90% and is not affected by food.
Metabolism
Undergoes negligible metabolism in humans. Less than 0.1% of the dose is excreted in the urine as metabolites.
Side Effects
Contraindications
- Known hypersensitivity to pregabalin or any of the excipients
Drug Interactions
ACE Inhibitors
Potential for angioedema when co-administered.
Opioids, Benzodiazepines, Ethanol
Increased central nervous system (CNS) depression, respiratory depression, and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and may include gastric lavage. Hemodialysis can effectively remove pregabalin from plasma.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to pregabalin or any of the excipients
Drug Interactions
ACE Inhibitors
Potential for angioedema when co-administered.
Opioids, Benzodiazepines, Ethanol
Increased central nervous system (CNS) depression, respiratory depression, and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and may include gastric lavage. Hemodialysis can effectively remove pregabalin from plasma.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pregabalin for its approved indications.
Lab Monitoring
- No routine laboratory monitoring is typically required. Renal function should be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Emphasize the importance of gradual dose reduction to minimize withdrawal symptoms.
- Counsel patients on potential for dizziness and somnolence, advising caution with driving and machinery.
- Monitor patients for signs of suicidal ideation and depression, especially at the start of treatment or after dose changes.
Patient Guidelines
- Do not stop taking Lyric abruptly; gradually reduce the dose under medical supervision to avoid withdrawal symptoms.
- Lyric may cause dizziness and somnolence; avoid driving or operating heavy machinery until you know how it affects you.
- Avoid alcohol consumption while taking this medication as it can increase CNS depression.
- Report any mood changes, suicidal thoughts, or unusual behaviors to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Lyric can cause dizziness, somnolence, and blurred vision, which may impair your ability to drive or operate machinery. Patients should be advised not to drive or operate complex machinery until they have gained sufficient experience with Lyric to gauge whether it adversely affects their ability.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
- Practice stress management techniques to help cope with chronic pain or anxiety.
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