Lyric
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lyric 50 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain agent used to treat various conditions like neuropathic pain, fibromyalgia, and certain types of seizures. It works by affecting chemicals in the brain that send pain signals.
Uses & Indications
Dosage
Adults
Initial dosage for most indications is 50 mg three times daily (150 mg/day). May be adjusted up to 300-600 mg/day in divided doses based on individual response and tolerability. For GAD, the starting dose is 150 mg/day, increased to 300 mg/day after one week, and then to 450 mg/day if needed.
Elderly
Elderly patients may require lower doses due to potential for decreased renal function. Dosage adjustment should be based on creatinine clearance.
Renal_impairment
Dosage adjustment is required in patients with impaired renal function. The total daily dose should be reduced based on creatinine clearance (e.g., for CrCl 30-60 mL/min, total daily dose should be 75-300 mg in 2-3 divided doses).
How to Take
Lyric capsules can be taken with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which leads to a reduction in the release of several neurotransmitters including glutamate, norepinephrine, and substance P. This action results in its analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Variable; for neuropathic pain, some effects may be seen within 1 week, with full effects taking several weeks. For fibromyalgia, improvement may begin within 1-2 weeks.
Excretion
Primarily excreted unchanged in the urine. Renal clearance is directly proportional to creatinine clearance.
Half life
Approximately 6.3 hours. It is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.
Absorption
Rapidly absorbed following oral administration, with peak plasma concentrations occurring within 1.5 hours. Oral bioavailability is estimated to be ≥90% and is independent of dose.
Metabolism
Negligible; less than 2% of the dose is metabolized in humans.
Side Effects
Contraindications
- Known hypersensitivity to pregabalin or to any of the excipients in the formulation.
Drug Interactions
Angiotensin-converting enzyme (ACE) inhibitors
Concomitant use with ACE inhibitors has been associated with an increased risk of angioedema (swelling of the face, limbs, lips, tongue, glottis and/or larynx).
CNS depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the effects of pregabalin on the central nervous system, leading to increased drowsiness, dizziness, and respiratory depression. Concomitant use should be approached with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. In rare cases, coma and seizures have been reported. Management is primarily supportive care and symptomatic treatment. Hemodialysis may be effective if clinically indicated.
Pregnancy & Lactation
Pregnancy Category C: Use only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to pregabalin or to any of the excipients in the formulation.
Drug Interactions
Angiotensin-converting enzyme (ACE) inhibitors
Concomitant use with ACE inhibitors has been associated with an increased risk of angioedema (swelling of the face, limbs, lips, tongue, glottis and/or larynx).
CNS depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the effects of pregabalin on the central nervous system, leading to increased drowsiness, dizziness, and respiratory depression. Concomitant use should be approached with caution.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. In rare cases, coma and seizures have been reported. Management is primarily supportive care and symptomatic treatment. Hemodialysis may be effective if clinically indicated.
Pregnancy & Lactation
Pregnancy Category C: Use only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing woman. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies
Approval Status
FDA Approved
Patent Status
Expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pregabalin across its approved indications, including neuropathic pain, fibromyalgia, and partial-onset seizures. Studies have shown significant reductions in pain scores and improvements in quality of life.
Lab Monitoring
- Routine lab monitoring is generally not required for pregabalin therapy. However, renal function should be monitored in elderly patients or those with pre-existing renal impairment, and dosage adjusted accordingly. Liver function tests may be considered in patients with pre-existing hepatic disease, although pregabalin is minimally metabolized by the liver.
Doctor Notes
- Advise patients about the potential for dizziness and somnolence, and the risk of falls, especially at the initiation of therapy or after dose adjustments.
- Emphasize the importance of gradual dose reduction when discontinuing pregabalin to minimize withdrawal symptoms.
- Monitor patients for signs of abuse or dependence, particularly in those with a history of substance abuse. Assess for suicidal thoughts or behavior.
- Counsel patients on avoiding alcohol and other CNS depressants during treatment.
Patient Guidelines
- Do not stop taking Lyric suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- Lyric may cause dizziness and drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
- Avoid alcohol while taking this medicine, as it can increase side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lyric may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution and avoid such activities until you are sure you can perform them safely.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in regular, moderate exercise if possible.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
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