Maprocin
Generic Name
Azimaprocin
Manufacturer
PharmaGlobal Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maprocin 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Maprocin 500 mg Tablet is a broad-spectrum macrolide antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily on days 2-5.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Maprocin tablets can be taken orally with or without food. For best absorption, it is often recommended to take it an hour before or two hours after meals, though this is less critical than for some other macrolides.
Mechanism of Action
Azimaprocin acts by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of susceptible microorganisms, thereby interfering with the translocation of peptides and inhibiting RNA-dependent protein synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-3 hours.
Excretion
Mainly excreted unchanged in bile, with a small amount excreted via urine.
Half life
Approximately 48-72 hours, due to extensive tissue uptake and slow release.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is about 37%.
Metabolism
Primarily hepatic, via demethylation.
Side Effects
Contraindications
- Hypersensitivity to azimaprocin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azimaprocin use.
Drug Interactions
Warfarin
Increased anticoagulant effect (INR) has been reported. Monitor INR closely.
Nelfinavir
Increased serum concentrations of azimaprocin. Monitor for side effects.
Antacids (containing aluminum or magnesium)
May reduce the absorption of azimaprocin. Take azimaprocin at least 1-2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and general supportive measures are indicated. Hemodialysis and peritoneal dialysis are not effective in removing azimaprocin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Azimaprocin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to azimaprocin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azimaprocin use.
Drug Interactions
Warfarin
Increased anticoagulant effect (INR) has been reported. Monitor INR closely.
Nelfinavir
Increased serum concentrations of azimaprocin. Monitor for side effects.
Antacids (containing aluminum or magnesium)
May reduce the absorption of azimaprocin. Take azimaprocin at least 1-2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and general supportive measures are indicated. Hemodialysis and peritoneal dialysis are not effective in removing azimaprocin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Azimaprocin is excreted into breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent granted
WHO Essential Medicine
YesClinical Trials
Post-marketing surveillance and ongoing clinical trials continue to evaluate the long-term efficacy and safety profile of Azimaprocin.
Lab Monitoring
- Liver function tests (LFTs) if prolonged treatment or history of hepatic dysfunction.
- INR monitoring if co-administered with warfarin.
Doctor Notes
- Counsel patients on the importance of completing the full course of therapy.
- Monitor liver function tests in patients with pre-existing hepatic impairment or during prolonged treatment.
- Be aware of potential drug interactions, especially with warfarin and antacids.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Do not share your medication with others.
- Inform your doctor if you experience any severe side effects or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Azimaprocin may cause dizziness in some patients. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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