Maprocin
Generic Name
Naproxen 750 mg tablet
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maprocin 750 mg tablet | ৳ 18.16 | ৳ 181.60 |
Description
Overview of the medicine
Maprocin 750 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is effective in treating various rheumatic conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, and dysmenorrhea.
Uses & Indications
Dosage
Adults
Typically 750 mg to 1500 mg daily, divided into two doses. For acute pain or gout, an initial dose of 750 mg, followed by 250 mg every 8 hours as needed.
Elderly
Should start with a lower dose and use with caution due to increased risk of adverse effects.
Renal_impairment
Dosage reduction or avoidance may be necessary in patients with impaired renal function.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the whole tablet with water; do not chew or crush it.
Mechanism of Action
Maprocin works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which reduces prostaglandin synthesis. Prostaglandins are responsible for causing pain, inflammation, and fever. By decreasing prostaglandins, it effectively alleviates these symptoms.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Mainly excreted via urine.
Half life
12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- For peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
May increase plasma lithium concentrations.
Warfarin
Increased risk of bleeding.
Methotrexate
May increase methotrexate toxicity.
ACE Inhibitors and Diuretics
May reduce the efficacy of these drugs and increase the risk of renal impairment.
Storage
Store below 25°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and activated charcoal may be considered. Symptomatic and supportive treatment should be provided.
Pregnancy & Lactation
Should not be used during the third trimester of pregnancy. Consult a doctor before use during the first and second trimesters. Use with caution in breastfeeding mothers as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- For peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
May increase plasma lithium concentrations.
Warfarin
Increased risk of bleeding.
Methotrexate
May increase methotrexate toxicity.
ACE Inhibitors and Diuretics
May reduce the efficacy of these drugs and increase the risk of renal impairment.
Storage
Store below 25°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and activated charcoal may be considered. Symptomatic and supportive treatment should be provided.
Pregnancy & Lactation
Should not be used during the third trimester of pregnancy. Consult a doctor before use during the first and second trimesters. Use with caution in breastfeeding mothers as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired, available as generic
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have been conducted to establish the efficacy and safety of Naproxen, supporting its use in various pain and inflammatory conditions.
Lab Monitoring
- Renal function (creatinine, BUN) for long-term therapy
- Hepatic function (ALT, AST)
- Complete blood count (CBC)
Doctor Notes
- Assess patient's gastrointestinal and cardiovascular risk factors for long-term use.
- Dose adjustment required in patients with renal or hepatic impairment.
- Be aware of interactions with other NSAIDs or anticoagulants.
Patient Guidelines
- Take the medicine as directed by your doctor.
- Take with food or milk to reduce stomach upset.
- Do not exceed the prescribed dose.
- Report any unusual side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not take two doses at once.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances in some individuals. If these symptoms occur, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid alcohol consumption during treatment.
- Drink adequate water.
- If using long-term, ensure regular follow-ups with your doctor.
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