Maxpro
Generic Name
Esomeprazole
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxpro 20 mg capsule | ৳ 7.00 | ৳ 98.00 |
Description
Overview of the medicine
Maxpro 20 mg Capsule contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Maintenance: 20 mg once daily. H. pylori: 20 mg twice daily for 7-10 days (with antibiotics). Zollinger-Ellison: 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is needed for patients with renal impairment.
How to Take
Take the capsule orally, at least one hour before a meal. Swallow whole with water; do not chew or crush. For patients who have difficulty swallowing, the capsule can be opened and the pellets mixed with a small amount of water or soft food.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid secretion, thereby reducing gastric acidity.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted primarily in urine (80%) and feces (20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 64% after a single 20 mg dose, increasing to 89% with repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.
Methotrexate
Increased methotrexate levels; monitor for toxicity.
Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, headache, and sweating. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so caution is advised; weigh benefits against risks.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel; consider alternative antiplatelet therapy.
Methotrexate
Increased methotrexate levels; monitor for toxicity.
Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C, in a dry place, away from light. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, headache, and sweating. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, so caution is advised; weigh benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of esomeprazole in acid-related disorders. Studies have demonstrated superior healing rates for erosive esophagitis compared to older PPIs.
Lab Monitoring
- No routine laboratory monitoring is typically required for short-term use.
- For long-term use, monitor magnesium levels, especially in patients taking diuretics or other drugs that can lower magnesium.
- Monitor INR for patients on warfarin.
Doctor Notes
- Advise patients on lifestyle modifications alongside medication.
- Consider lowest effective dose for shortest duration.
- Monitor for C. difficile infection if diarrhea occurs.
- Counsel patients on potential long-term risks with prolonged PPI use.
Patient Guidelines
- Take the capsule at least one hour before your first meal of the day.
- Do not crush or chew the capsule; swallow it whole.
- If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Maxpro generally does not affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn, such as fatty foods, spicy foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed to reduce nighttime reflux.
- Maintain a healthy weight.
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