Maxpro
Generic Name
Esomeprazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxpro 40 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD/Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily. H. pylori eradication: 20 mg twice daily for 7-14 days with appropriate antibiotics.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients due to potential comorbidities.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Swallow the tablet whole with water, preferably at least one hour before a meal. Do not chew or crush.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted in urine (80%) and feces (20%).
Half life
Approximately 1.5 hours
Absorption
Rapidly absorbed after oral administration, with bioavailability of approximately 64% (single dose) to 89% (repeated doses).
Metabolism
Extensively metabolized in the liver by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Diazepam
Decreased clearance of diazepam, leading to increased plasma concentrations.
Warfarin
Increased INR and prothrombin time, potentially leading to abnormal bleeding. Monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Avoid concomitant use.
Drugs dependent on gastric pH (e.g., ketoconazole, iron salts)
Altered absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms are generally mild and reversible. Treatment should be symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Esomeprazole is excreted in human breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Diazepam
Decreased clearance of diazepam, leading to increased plasma concentrations.
Warfarin
Increased INR and prothrombin time, potentially leading to abnormal bleeding. Monitor closely.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Avoid concomitant use.
Drugs dependent on gastric pH (e.g., ketoconazole, iron salts)
Altered absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms are generally mild and reversible. Treatment should be symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Esomeprazole is excreted in human breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of esomeprazole in treating GERD, erosive esophagitis, and peptic ulcers.
Lab Monitoring
- No routine lab monitoring required. In long-term therapy, monitor for vitamin B12 levels and magnesium levels (hypomagnesemia).
- Monitor liver function tests in patients with severe hepatic impairment.
Doctor Notes
- Exclude malignancy, especially in patients with alarm symptoms, before initiating esomeprazole therapy.
- Advise patients on potential long-term risks (e.g., C. difficile, fractures, hypomagnesemia) and monitor as appropriate.
- Consider lowest effective dose and shortest duration of therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not crush or chew the tablet; swallow it whole.
- If you experience any severe or persistent side effects, contact your doctor immediately.
- Do not stop taking the medicine suddenly without consulting your doctor, as symptoms may return.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages that worsen your symptoms (e.g., spicy, fatty, acidic foods, caffeine, alcohol).
- Elevate the head of your bed if you suffer from GERD.
- Maintain a healthy weight and quit smoking for better digestive health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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