Merocil
Generic Name
Cefixime
Manufacturer
NIPRO JMI Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| merocil 1 gm injection | ৳ 1,594.78 | N/A |
| merocil 250 mg injection | ৳ 400.00 | N/A |
| merocil 500 mg injection | ৳ 852.56 | N/A |
Description
Overview of the medicine
Merocil contains Cefixime, a third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Adults and children over 12 years: 200 mg once daily or 400 mg once daily, depending on infection severity. For uncomplicated gonorrhea, 400 mg single dose.
Elderly
No specific dose adjustment needed unless severe renal impairment.
Renal_impairment
Dose adjustment required for creatinine clearance less than 60 mL/min.
How to Take
Can be taken with or without food. For best absorption, it is often recommended with food to minimize gastrointestinal upset.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Primarily renal (glomerular filtration and tubular secretion); some biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Well absorbed orally, bioavailability 40-50%.
Metabolism
Minimally metabolized; primarily eliminated as unchanged drug.
Side Effects
Contraindications
- •Known hypersensitivity to cefixime or other cephalosporins
- •History of anaphylactic reactions to penicillin
Drug Interactions
Warfarin
Increased prothrombin time/INR. Monitor coagulation parameters.
Carbamazepine
Elevated carbamazepine levels due to reduced metabolism.
Oral Contraceptives
Reduced efficacy of oral contraceptives (rare). Advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Gastric lavage, symptomatic and supportive treatment. Hemodialysis or peritoneal dialysis is not effective in removing cefixime.
Pregnancy & Lactation
Pregnancy category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential side effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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