Methsolon
Generic Name
methsolon-1-gm-injection
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methsolon 1 gm injection | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Methylprednisolone is a synthetic glucocorticoid used for its potent anti-inflammatory and immunosuppressive effects. It is a high-dose corticosteroid often used in acute and severe conditions.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition and severity, typically 10-250 mg IV/IM, up to 1 gm daily for severe cases (e.g., MS exacerbations, organ transplant rejection). High doses are usually administered for short periods.
Elderly
No specific dose adjustment is usually needed, but close monitoring for adverse effects is recommended due to potential comorbidities.
Renal_impairment
No specific dose adjustment is generally needed for renal impairment, but caution is advised in fluid retention cases.
How to Take
Methsolon 1 gm injection is typically administered intravenously (IV) as a slow bolus or infusion, or intramuscularly (IM) into a large muscle mass. The reconstituted solution must be used promptly.
Mechanism of Action
Methylprednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene expression. This leads to the inhibition of inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppression of immune cell activity, resulting in potent anti-inflammatory and immunosuppressive effects.
Pharmacokinetics
Onset
Varies by condition and route of administration; intravenous effects usually begin within minutes to hours.
Excretion
Mainly excreted in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2.5 to 3.5 hours, but the biological half-life (duration of action) is much longer (18-36 hours).
Absorption
Rapidly absorbed after intramuscular or intravenous administration. Peak plasma concentrations are typically reached within 1 hour.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any excipients
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy (immunosuppression may occur)
Drug Interactions
Anticoagulants (e.g., warfarin)
Corticosteroids may potentiate or inhibit the effects of anticoagulants; close monitoring of INR is required.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 Inducers (e.g., phenobarbital, rifampicin)
May decrease methylprednisolone plasma levels, requiring dose adjustment.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase methylprednisolone plasma levels, potentially leading to increased adverse effects.
Storage
Store the unopened vials below 30°C (86°F), protected from light and moisture. Do not freeze. Store the reconstituted solution at room temperature or refrigerated (2-8°C) and use within the recommended timeframe.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hyperglycemia, and hypertension. Management is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Use with caution during pregnancy; benefits must outweigh potential risks to the fetus. Corticosteroids are excreted in breast milk; advise against breastfeeding during high-dose therapy or consider alternative feeding methods.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any excipients
- Administration of live or live-attenuated vaccines during high-dose corticosteroid therapy (immunosuppression may occur)
Drug Interactions
Anticoagulants (e.g., warfarin)
Corticosteroids may potentiate or inhibit the effects of anticoagulants; close monitoring of INR is required.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 Inducers (e.g., phenobarbital, rifampicin)
May decrease methylprednisolone plasma levels, requiring dose adjustment.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase methylprednisolone plasma levels, potentially leading to increased adverse effects.
Storage
Store the unopened vials below 30°C (86°F), protected from light and moisture. Do not freeze. Store the reconstituted solution at room temperature or refrigerated (2-8°C) and use within the recommended timeframe.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hyperglycemia, and hypertension. Management is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Use with caution during pregnancy; benefits must outweigh potential risks to the fetus. Corticosteroids are excreted in breast milk; advise against breastfeeding during high-dose therapy or consider alternative feeding methods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date when stored correctly. The reconstituted solution has a limited shelf life (e.g., 48 hours) at room temperature or refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has been extensively studied in numerous clinical trials for its efficacy in a wide range of inflammatory, autoimmune, and immunosuppressive conditions. Ongoing research focuses on optimizing dosing regimens and exploring new therapeutic applications.
Lab Monitoring
- Blood glucose levels (especially in diabetics)
- Electrolyte levels (particularly potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Growth in children (for prolonged pediatric use)
- Ophthalmic examinations (for long-term use)
Doctor Notes
- Always consider the lowest effective dose for the shortest possible duration to minimize adverse effects.
- Gradually taper the dose when discontinuing treatment to prevent acute adrenal insufficiency.
- Monitor patients closely for signs of infection, hyperglycemia, hypertension, and fluid retention.
- Educate patients on the importance of not abruptly stopping the medication and reporting any unusual symptoms.
Patient Guidelines
- Do not stop this medicine suddenly without consulting your doctor, as it can lead to severe withdrawal symptoms or adrenal crisis.
- Report any signs of infection (fever, sore throat, pain) immediately, as your immune system may be suppressed.
- If you are diabetic, monitor your blood sugar levels closely as this medicine can increase them.
- Avoid close contact with people who have infections, especially chickenpox or measles, if you have not had them before.
Missed Dose Advice
If a dose is missed, contact your healthcare provider for advice. Do not double the dose to catch up.
Driving Precautions
Methylprednisolone may cause dizziness, vertigo, or visual disturbances in some patients. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially during long-term therapy.
- Limit sodium intake to help manage fluid retention and high blood pressure.
- Engage in regular, moderate exercise (if medically permitted) to maintain muscle strength and bone density.
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