Methsolon
Generic Name
Methylprednisolone
Manufacturer
ABC Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methsolon 40 mg injection | ৳ 100.00 | N/A |
Description
Overview of the medicine
Methsolon 40 mg Injection contains Methylprednisolone, a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive effects. It is indicated for a wide range of conditions including severe allergies, asthma, rheumatic disorders, skin conditions, and certain cancers.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the specific condition, severity, and patient response. Typically, for conditions requiring rapid effect, initial doses range from 10 mg to 80 mg intramuscularly once daily or every 1-2 weeks. For severe acute conditions, higher doses may be used intravenously.
Elderly
No specific dose adjustment is generally required, but caution is advised due to increased susceptibility to side effects. The lowest effective dose should be used.
Renal_impairment
No specific dosage adjustment is usually necessary for renal impairment, but caution is advised. Methylprednisolone is largely metabolized in the liver.
How to Take
For intramuscular (IM) injection, inject deeply into a large muscle mass (e.g., gluteal muscle). For intravenous (IV) injection (only sodium succinate form), administer slowly over several minutes or as an infusion. Do not inject the acetate form intravenously.
Mechanism of Action
Methylprednisolone exerts its action by binding to specific glucocorticoid receptors in the cytoplasm. The activated receptor-steroid complex then translocates to the nucleus, where it modulates the transcription of various genes, leading to inhibition of inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppression of immune responses.
Pharmacokinetics
Onset
Onset of action is typically within 1 hour for IV administration of methylprednisolone sodium succinate, and within 6-48 hours for IM administration of methylprednisolone acetate, with peak effects after a few days.
Excretion
Excreted predominantly by the kidneys as inactive metabolites. Minimal amounts excreted in bile.
Half life
Plasma half-life: 2.4-3.5 hours. Biological half-life: 18-36 hours.
Absorption
Rapidly absorbed after intramuscular administration. Bioavailability varies depending on the salt form and route of administration.
Metabolism
Primarily hepatic metabolism, mainly via CYP3A4-mediated 6β-hydroxylation.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Live or live-attenuated vaccines are contraindicated in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (e.g., Warfarin)
Methylprednisolone may either potentiate or inhibit the effects of anticoagulants; careful monitoring of INR is required.
Diuretics (e.g., Thiazides, Loop diuretics)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding when co-administered.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin, Barbiturates)
May increase methylprednisolone clearance, reducing its plasma levels and therapeutic effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Macrolide antibiotics, Grapefruit juice)
May decrease methylprednisolone clearance, increasing its plasma levels and risk of side effects.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with methylprednisolone is rare and usually does not lead to life-threatening situations. Symptoms may include Cushingoid features, electrolyte imbalance, hyperglycemia. No specific antidote is available. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit outweighs the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Lactation: Methylprednisolone is excreted in breast milk. Caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Live or live-attenuated vaccines are contraindicated in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
Anticoagulants (e.g., Warfarin)
Methylprednisolone may either potentiate or inhibit the effects of anticoagulants; careful monitoring of INR is required.
Diuretics (e.g., Thiazides, Loop diuretics)
May enhance potassium depletion.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of gastrointestinal ulceration and bleeding when co-administered.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin, Barbiturates)
May increase methylprednisolone clearance, reducing its plasma levels and therapeutic effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Macrolide antibiotics, Grapefruit juice)
May decrease methylprednisolone clearance, increasing its plasma levels and risk of side effects.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose with methylprednisolone is rare and usually does not lead to life-threatening situations. Symptoms may include Cushingoid features, electrolyte imbalance, hyperglycemia. No specific antidote is available. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit outweighs the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Lactation: Methylprednisolone is excreted in breast milk. Caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Check the product label for specific shelf-life. Typically 2-3 years when stored unopened under recommended conditions. Reconstituted solution should be used promptly.
Availability
Available in hospitals, clinics, and retail pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has been extensively studied in numerous clinical trials supporting its efficacy and safety across a wide range of inflammatory, autoimmune, and neoplastic conditions. Ongoing research continues to explore new applications and optimize dosing regimens.
Lab Monitoring
- Blood pressure monitoring
- Blood glucose levels (especially in diabetic patients)
- Electrolyte levels (potassium, sodium)
- Bone mineral density (for long-term use)
- Ophthalmic exams (for long-term use, to check for cataracts/glaucoma)
- Adrenal function tests (after withdrawal)
Doctor Notes
- Emphasize the importance of gradual tapering of the dose, especially after prolonged therapy, to prevent adrenal insufficiency.
- Monitor patients for signs of infection, hyperglycemia, and electrolyte imbalances.
- Advise on bone health strategies (calcium/Vit D supplementation) for patients on long-term therapy.
- Assess for gastrointestinal upset and consider prophylaxis if high risk.
Patient Guidelines
- Do not stop this medicine abruptly, especially after long-term use, as it can lead to withdrawal symptoms or adrenal insufficiency. Always follow your doctor's instructions for tapering the dose.
- Report any unusual side effects, signs of infection (fever, sore throat), or changes in mood/behavior to your doctor immediately.
- Carry identification indicating that you are taking a steroid, especially if you have an emergency.
- Avoid close contact with people who are sick or have infections like chickenpox or measles, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Methylprednisolone generally does not impair the ability to drive or operate machinery. However, if you experience dizziness, blurred vision, or muscle weakness, avoid such activities until these symptoms resolve.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Engage in regular, moderate exercise to maintain muscle strength and overall well-being.
- Monitor blood sugar levels closely if you have diabetes or are at risk of developing it.
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