Methsolon
Generic Name
Methylprednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methsolon 16 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Methylprednisolone is a synthetic glucocorticoid used for its potent anti-inflammatory and immunosuppressive effects. It is widely prescribed for various allergic, inflammatory, and autoimmune conditions.
Uses & Indications
Dosage
Adults
Dosage is highly individualized based on the disease being treated and patient response. Typically ranges from 4 mg to 48 mg daily, given as a single dose or in divided doses. For Methsolon 16 mg, common starting doses might be 16-32 mg daily.
Elderly
No specific dose adjustment is usually required, but caution is advised due to potential age-related decrease in renal/hepatic function and increased susceptibility to adverse effects.
Renal_impairment
No routine dosage adjustment is necessary for renal impairment, but clinical monitoring is recommended.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not stop taking the medicine suddenly without consulting your doctor, as it may lead to withdrawal symptoms.
Mechanism of Action
Methylprednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to increased synthesis of anti-inflammatory proteins and decreased synthesis of pro-inflammatory mediators, thereby suppressing immune and inflammatory responses.
Pharmacokinetics
Onset
Variable, with therapeutic effects often observed within hours to days depending on the condition.
Excretion
Excreted mainly via the kidneys as metabolites.
Half life
Plasma half-life is approximately 2-3 hours; biological half-life is 18-36 hours.
Absorption
Well absorbed orally, with peak plasma concentrations typically achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Anticoagulants
Corticosteroids may alter the effects of anticoagulants; close monitoring of INR/PT is advised.
Diuretics (Thiazide or Loop)
May enhance potassium depletion.
CYP3A4 Inducers (e.g., Phenobarbital, Rifampin)
May decrease methylprednisolone plasma concentrations and effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase methylprednisolone plasma concentrations and effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include electrolyte imbalance, fluid retention, hypertension, and hyperglycemia. Treatment is supportive and symptomatic; no specific antidote is available. Chronic overdose can lead to Cushingoid features.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Methylprednisolone is excreted in breast milk; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
Anticoagulants
Corticosteroids may alter the effects of anticoagulants; close monitoring of INR/PT is advised.
Diuretics (Thiazide or Loop)
May enhance potassium depletion.
CYP3A4 Inducers (e.g., Phenobarbital, Rifampin)
May decrease methylprednisolone plasma concentrations and effects.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase methylprednisolone plasma concentrations and effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include electrolyte imbalance, fluid retention, hypertension, and hyperglycemia. Treatment is supportive and symptomatic; no specific antidote is available. Chronic overdose can lead to Cushingoid features.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Methylprednisolone is excreted in breast milk; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, refer to the specific product packaging for exact details.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has undergone extensive clinical trials supporting its efficacy and safety across a wide range of inflammatory, allergic, and autoimmune conditions. Ongoing research continues to optimize its use and explore new applications.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients or those at risk)
- Electrolyte levels (particularly potassium)
- Blood pressure
- Bone mineral density (for long-term therapy)
- Growth monitoring in pediatric patients
Doctor Notes
- Emphasize the importance of gradual dose tapering to prevent adrenal insufficiency.
- Monitor for signs of infection, blood glucose levels, blood pressure, and bone health in patients on chronic therapy.
- Consider calcium and vitamin D supplementation for patients on long-term corticosteroid treatment to mitigate osteoporosis risk.
Patient Guidelines
- Do not stop taking Methsolon suddenly; always follow your doctor's instructions for tapering the dose.
- Report any unusual side effects, especially severe mood changes or signs of infection.
- Carry an identification card or medical alert bracelet if you are on long-term corticosteroid therapy.
- Avoid close contact with people who have chickenpox or measles, as corticosteroids can reduce your immunity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Methylprednisolone generally does not affect the ability to drive or operate machinery. However, if you experience side effects like dizziness, visual disturbances, or mood changes, avoid such activities.
Lifestyle Advice
- Adopt a low-sodium, high-potassium, and high-protein diet to counteract potential side effects.
- Engage in regular weight-bearing exercise to help maintain bone health, especially during long-term therapy.
- Monitor blood sugar levels if you have diabetes or are at risk.
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