Methsolon
Generic Name
Methylprednisolone Sodium Succinate
Manufacturer
XYZ Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methsolon 500 mg injection | ৳ 600.00 | N/A |
Description
Overview of the medicine
Methsolon 500 mg Injection contains Methylprednisolone, a potent synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used to treat various conditions including severe allergic reactions, inflammatory diseases, and certain autoimmune disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition. For acute severe conditions, 125 mg to 1000 mg IV once daily or divided doses. For acute asthma: 40-80 mg IV every 6-8 hours. For shock: 30 mg/kg IV infused over 10-20 minutes, repeated every 4-6 hours if necessary for 48 hours.
Elderly
Generally, use lowest effective dose. Monitor for side effects more closely.
Renal_impairment
No specific dose adjustment typically required, but monitor fluid and electrolyte balance.
How to Take
For intravenous (IV) or intramuscular (IM) use. Reconstitute powder with appropriate diluent (e.g., sterile water for injection) before use. IV administration should be slow, over several minutes for smaller doses and 30-60 minutes for higher doses (e.g., 500mg).
Mechanism of Action
Methylprednisolone works by binding to intracellular glucocorticoid receptors, modifying gene expression to inhibit the synthesis of inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppressing immune cell function. It also stabilizes lysosomal membranes and decreases capillary permeability.
Pharmacokinetics
Onset
Minutes to hours, depending on route and condition.
Excretion
Mainly renal as inactive metabolites.
Half life
Plasma half-life: ~2-3 hours; Biological half-life: 18-36 hours.
Absorption
Rapidly and completely absorbed following intramuscular administration. Bioavailability is high.
Metabolism
Primarily hepatic via cytochrome P450 3A4 (CYP3A4).
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May alter anticoagulant effect; monitor INR.
Diuretics (thiazide, loop)
May enhance potassium depletion.
CYP3A4 inducers (e.g., rifampin, phenytoin)
May decrease methylprednisolone levels and effects.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase methylprednisolone levels and effects.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Reconstituted solution should be used promptly, within 48 hours if refrigerated.
Overdose
Symptoms of acute overdose are rare. Chronic overdose can lead to Cushingoid features, adrenal suppression, and other corticosteroid-related side effects. Treatment is symptomatic and supportive; gradual withdrawal is necessary if chronic overdose occurs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May alter anticoagulant effect; monitor INR.
Diuretics (thiazide, loop)
May enhance potassium depletion.
CYP3A4 inducers (e.g., rifampin, phenytoin)
May decrease methylprednisolone levels and effects.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase methylprednisolone levels and effects.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Reconstituted solution should be used promptly, within 48 hours if refrigerated.
Overdose
Symptoms of acute overdose are rare. Chronic overdose can lead to Cushingoid features, adrenal suppression, and other corticosteroid-related side effects. Treatment is symptomatic and supportive; gradual withdrawal is necessary if chronic overdose occurs.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date. Refer to package insert for specific expiry date.
Availability
Hospitals, Pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions. Ongoing research explores new indications and optimized dosing regimens.
Lab Monitoring
- Blood pressure
- Blood glucose
- Electrolytes (especially potassium)
- Bone mineral density (long-term use)
- Ophthalmologic exams (long-term use)
Doctor Notes
- Consider potential for adrenal suppression, especially with prolonged use; taper dose gradually.
- Monitor for signs of infection and manage proactively.
- Educate patients on potential side effects and importance of adherence.
Patient Guidelines
- Do not stop the medication suddenly without consulting your doctor.
- Report any unusual side effects immediately.
- Avoid contact with people who have infections, especially chickenpox or measles.
Missed Dose Advice
As this is an injection administered by a healthcare professional, missed doses are rare. If a scheduled dose is missed, contact your doctor or nurse immediately to reschedule.
Driving Precautions
Methylprednisolone generally does not impair driving ability. However, if you experience dizziness or visual disturbances, avoid driving.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Regular exercise (if medically appropriate).
- Limit salt intake to reduce fluid retention.
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