moxilocin
Generic Name
Moxifloxacin 400 mg Injection
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxilocin 400 mg injection | ৳ 350.00 | N/A |
Description
Overview of the medicine
Moxifloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections, including respiratory, skin, and intra-abdominal infections. The 400 mg injection is administered intravenously.
Uses & Indications
Dosage
Adults
400 mg administered once daily by intravenous infusion over 60 minutes.
Elderly
No dosage adjustment usually required based on age alone.
Renal_impairment
No dosage adjustment required for mild to severe renal impairment or in patients on hemodialysis or CAPD.
How to Take
Administer intravenously over a period of 60 minutes. Do not administer as a rapid or bolus injection.
Mechanism of Action
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid (within minutes for IV administration).
Excretion
Excreted via both renal (approx. 20%) and fecal/biliary (approx. 25%) routes as unchanged drug and metabolites.
Half life
Approximately 12-15 hours.
Absorption
Rapidly and almost completely absorbed when administered orally; IV administration bypasses absorption.
Metabolism
Partially metabolized in the liver via Phase II glucuronide and sulfate conjugation.
Side Effects
Contraindications
- •Hypersensitivity to moxifloxacin or other quinolones
- •History of tendinitis or tendon rupture associated with fluoroquinolone use
- •QTc prolongation
- •Uncorrected hypokalemia
Drug Interactions
Warfarin
May potentiate anticoagulant effect.
QTc-prolonging drugs
Increased risk of QTc prolongation (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics).
Antacids, Iron, Zinc, Sucralfate, Didanosine
May reduce absorption if given orally (less relevant for IV but still a general drug interaction).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. ECG monitoring is recommended due to the risk of QTc prolongation. Hemodialysis or peritoneal dialysis is not effective in removing moxifloxacin.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to the product label for specific details.
Availability
Hospitals, retail pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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