moxilocin
Generic Name
Moxifloxacin 400 mg Injection
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxilocin 400 mg injection | ৳ 350.00 | N/A |
Description
Overview of the medicine
Moxifloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections, including respiratory, skin, and intra-abdominal infections. The 400 mg injection is administered intravenously.
Uses & Indications
Dosage
Adults
400 mg administered once daily by intravenous infusion over 60 minutes.
Elderly
No dosage adjustment usually required based on age alone.
Renal_impairment
No dosage adjustment required for mild to severe renal impairment or in patients on hemodialysis or CAPD.
How to Take
Administer intravenously over a period of 60 minutes. Do not administer as a rapid or bolus injection.
Mechanism of Action
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid (within minutes for IV administration).
Excretion
Excreted via both renal (approx. 20%) and fecal/biliary (approx. 25%) routes as unchanged drug and metabolites.
Half life
Approximately 12-15 hours.
Absorption
Rapidly and almost completely absorbed when administered orally; IV administration bypasses absorption.
Metabolism
Partially metabolized in the liver via Phase II glucuronide and sulfate conjugation.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- QTc prolongation
- Uncorrected hypokalemia
Drug Interactions
Warfarin
May potentiate anticoagulant effect.
QTc-prolonging drugs
Increased risk of QTc prolongation (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics).
Antacids, Iron, Zinc, Sucralfate, Didanosine
May reduce absorption if given orally (less relevant for IV but still a general drug interaction).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. ECG monitoring is recommended due to the risk of QTc prolongation. Hemodialysis or peritoneal dialysis is not effective in removing moxifloxacin.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- QTc prolongation
- Uncorrected hypokalemia
Drug Interactions
Warfarin
May potentiate anticoagulant effect.
QTc-prolonging drugs
Increased risk of QTc prolongation (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics).
Antacids, Iron, Zinc, Sucralfate, Didanosine
May reduce absorption if given orally (less relevant for IV but still a general drug interaction).
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. ECG monitoring is recommended due to the risk of QTc prolongation. Hemodialysis or peritoneal dialysis is not effective in removing moxifloxacin.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to potential risks to the fetus/infant (e.g., cartilage damage). Use only if the potential benefit justifies the potential risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to the product label for specific details.
Availability
Hospitals, retail pharmacies
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Moxifloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, often showing non-inferiority or superiority to comparator antibiotics.
Lab Monitoring
- Renal and hepatic function tests (if underlying conditions exist)
- Electrolytes (Potassium, Magnesium)
- ECG monitoring (especially with risk factors for QTc prolongation)
Doctor Notes
- Assess patients for risk factors of QTc prolongation before initiation.
- Counsel patients on black box warnings including tendinitis, tendon rupture, and peripheral neuropathy.
- Do not administer to patients with a history of myasthenia gravis.
Patient Guidelines
- Complete the full course of treatment even if you feel better.
- Report any unusual pain, especially in joints or muscles, immediately to your doctor.
- Avoid excessive sun exposure and use sunscreen.
- Do not drive or operate machinery if you experience dizziness or visual disturbances.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. Do not administer two doses at once to compensate for a missed dose.
Driving Precautions
Moxifloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to know how they react to moxifloxacin before driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated during treatment.
- Avoid excessive alcohol consumption as it may worsen gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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