Moxilocin
Generic Name
Moxifloxacin 400 mg Tablet
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxilocin 400 mg tablet | ৳ 45.00 | ৳ 450.00 |
Description
Overview of the medicine
Moxifloxacin is a fluoroquinolone antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and intra-abdominal infections.
Uses & Indications
Dosage
Adults
400 mg orally once daily for 5-21 days, depending on the infection.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment (including those on hemodialysis or CAPD).
How to Take
Take orally, with or without food. Tablets should be swallowed whole with sufficient liquid and not chewed.
Mechanism of Action
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 0.5 to 4 hours.
Excretion
Excreted both renally (approximately 20% as unchanged drug) and through the biliary/fecal route (approximately 25% as unchanged drug).
Half life
Approximately 12 hours.
Absorption
Rapid and almost complete absorption from the gastrointestinal tract. Bioavailability is approximately 90%.
Metabolism
Undergoes hepatic metabolism (Phase II, non-CYP) to form inactive sulfate and glucuronide conjugates.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones.
- History of tendinitis or tendon rupture associated with quinolone use.
- QTc prolongation or family history of QTc prolongation.
- Uncorrected hypokalemia or hypomagnesemia.
- Severe hepatic impairment (Child-Pugh Class C).
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR closely.
Antacids, iron, zinc, sucralfate
May reduce absorption of moxifloxacin; administer moxifloxacin several hours before or after these agents.
Class IA and III Antiarrhythmics (e.g., quinidine, amiodarone)
Increased risk of QTc prolongation; concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an acute overdose, supportive measures should be initiated. ECG monitoring is recommended due to the potential for QTc prolongation. Activated charcoal may be used for oral overdose if administered shortly after ingestion.
Pregnancy & Lactation
Moxifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk, and a decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones.
- History of tendinitis or tendon rupture associated with quinolone use.
- QTc prolongation or family history of QTc prolongation.
- Uncorrected hypokalemia or hypomagnesemia.
- Severe hepatic impairment (Child-Pugh Class C).
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR closely.
Antacids, iron, zinc, sucralfate
May reduce absorption of moxifloxacin; administer moxifloxacin several hours before or after these agents.
Class IA and III Antiarrhythmics (e.g., quinidine, amiodarone)
Increased risk of QTc prolongation; concomitant use is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of an acute overdose, supportive measures should be initiated. ECG monitoring is recommended due to the potential for QTc prolongation. Activated charcoal may be used for oral overdose if administered shortly after ingestion.
Pregnancy & Lactation
Moxifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk, and a decision should be made whether to discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA)
Patent Status
Expired for generic versions
Clinical Trials
Moxifloxacin has been extensively studied in numerous clinical trials for its approved indications, demonstrating efficacy and safety across various bacterial infections.
Lab Monitoring
- Electrocardiogram (ECG) for QTc interval, especially in patients with risk factors.
- Liver function tests (LFTs) if liver dysfunction is suspected.
- Electrolyte levels (potassium, magnesium) prior to and during therapy, especially in at-risk patients.
Doctor Notes
- Assess patient for risk factors of QTc prolongation before initiating therapy.
- Advise patients to report any signs of tendinitis, neuropathy, or CNS effects immediately.
- Use with caution in elderly patients and those with a history of seizures or myasthenia gravis.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Avoid excessive exposure to direct sunlight or artificial UV light while taking this medication.
- Report any tendon pain, swelling, or inflammation immediately.
- Discontinue the drug and consult a doctor if you experience symptoms of peripheral neuropathy (pain, burning, tingling, numbness, or weakness).
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Moxifloxacin may cause dizziness or visual disturbances, which could impair the ability to drive or operate machinery. Patients should be cautioned against performing such tasks until they are reasonably certain that the drug does not adversely affect them.
Lifestyle Advice
- Stay well-hydrated.
- Avoid excessive caffeine intake, as it may exacerbate CNS side effects.
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